{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu H"],"funding":["Shanghai Frontiers Science Center of Drug Target Identification and Delivery","Major Projects for Shanghai Zhangjiang National Independent Innovation of China","National Natural Science Foundation of China","National Innovation of Science and Technology-2030 (Program of Brain Science and Brain-Inspired IntelligenceTechnology) Grant of China"],"pagination":["e2408781"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809345"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Given the widespread presence of fluoroalkyl functionalities in bioactive molecules, the development of fluoroalkylation reactions with bench-stable and easy-to-use fluoroalkylating reagents is highly desirable. In addition, realization of mono-, di-, tri-, or polyfluoroalkyation usually requires distinct types of fluoroalkylating reagents under different or even harsh reaction conditions, and a universal method to accomplish different hydrofluoroalkylation of alkenes is lacking. Herein, the use of quaternary fluoroalkyl alcohols is reported as the universal fluoroalkylating reagents to readily facilitate mono-, di-, tri-, or polyfluoroalkylation of a wide range of alkene substrates in high yields. Moreover, a cascade reaction of hydrofluoroalkylation followed by intramolecular fluoroalkyl"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Diversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents."],"pmcid":["PMC11809345"],"funding_grant_id":["ZJ2021-ZD-007","ZXWH2170101","82304276 82273767","2021ZD0204004"],"pubmed_authors":["Zou Y","Lu H","Fan Z","Zhang A"],"additional_accession":[]},"is_claimable":false,"name":"Diversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents.","description":"Given the widespread presence of fluoroalkyl functionalities in bioactive molecules, the development of fluoroalkylation reactions with bench-stable and easy-to-use fluoroalkylating reagents is highly desirable. In addition, realization of mono-, di-, tri-, or polyfluoroalkyation usually requires distinct types of fluoroalkylating reagents under different or even harsh reaction conditions, and a universal method to accomplish different hydrofluoroalkylation of alkenes is lacking. Herein, the use of quaternary fluoroalkyl alcohols is reported as the universal fluoroalkylating reagents to readily facilitate mono-, di-, tri-, or polyfluoroalkylation of a wide range of alkene substrates in high yields. Moreover, a cascade reaction of hydrofluoroalkylation followed by intramolecular fluoroalkyl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T23:57:00.735Z","creation":"2025-04-04T23:57:00.735Z"},"accession":"S-EPMC11809345","cross_references":{"pubmed":["39718120"],"doi":["10.1002/advs.202408781"]}}