biostudies-literatureLu HShanghai Frontiers Science Center of Drug Target Identification and DeliveryMajor Projects for Shanghai Zhangjiang National Independent Innovation of ChinaNational Natural Science Foundation of ChinaNational Innovation of Science and Technology-2030 (Program of Brain Science and Brain-Inspired IntelligenceTechnology) Grant of Chinae2408781https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809345biostudies-literatureUnknown12(6)Given the widespread presence of fluoroalkyl functionalities in bioactive molecules, the development of fluoroalkylation reactions with bench-stable and easy-to-use fluoroalkylating reagents is highly desirable. In addition, realization of mono-, di-, tri-, or polyfluoroalkyation usually requires distinct types of fluoroalkylating reagents under different or even harsh reaction conditions, and a universal method to accomplish different hydrofluoroalkylation of alkenes is lacking. Herein, the use of quaternary fluoroalkyl alcohols is reported as the universal fluoroalkylating reagents to readily facilitate mono-, di-, tri-, or polyfluoroalkylation of a wide range of alkene substrates in high yields. Moreover, a cascade reaction of hydrofluoroalkylation followed by intramolecular fluoroalkylAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Diversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents.PMC11809345ZJ2021-ZD-007ZXWH217010182304276 822737672021ZD0204004Zou YLu HFan ZZhang AfalseDiversified Fluoroalkylation of Alkenes Using Quaternary Fluoroalkyl Alcohols as the Fluoroalkylating Reagents.Given the widespread presence of fluoroalkyl functionalities in bioactive molecules, the development of fluoroalkylation reactions with bench-stable and easy-to-use fluoroalkylating reagents is highly desirable. In addition, realization of mono-, di-, tri-, or polyfluoroalkyation usually requires distinct types of fluoroalkylating reagents under different or even harsh reaction conditions, and a universal method to accomplish different hydrofluoroalkylation of alkenes is lacking. Herein, the use of quaternary fluoroalkyl alcohols is reported as the universal fluoroalkylating reagents to readily facilitate mono-, di-, tri-, or polyfluoroalkylation of a wide range of alkene substrates in high yields. Moreover, a cascade reaction of hydrofluoroalkylation followed by intramolecular fluoroalkyl2025-01-01T00:00:00Z2025 Feb2025-04-04T23:57:00.735Z2025-04-04T23:57:00.735ZS-EPMC118093453971812010.1002/advs.202408781