{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang D"],"funding":["Research Personnel Cultivation Programme of Zhongda Hospital Southeast University","Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-level Hospital Pairing Assistance Construction Funds","Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Nanjing Life Health Science and Technology Project","National Natural Science Foundation of China","China Postdoctoral Science Foundation","National Key Research and Development Program","Jiangsu Provincial Medical Innovation Center","Postdoctoral Fellowship Program of CPSF"],"pagination":["e2410484"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809372"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Transarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water-in-oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L-arginine (L-Arg), which is known for its ability to modulate T-cell metabolism. The obtained L-Arg-loaded CaP-stabilized lipiodol Pickering emulsion (L-Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also en"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Arginine-Loaded Nano-Calcium-Phosphate-Stabilized Lipiodol Pickering Emulsions Potentiates Transarterial Embolization-Immunotherapy."],"pmcid":["PMC11809372"],"funding_grant_id":["2018YFA0704100","61821002","CXZX202219","52032008","CZXM-GSP-RC81","BX20230068","2024M750454","82302330","2024M750452","82130060","2018YFA0704104","82402408","202205045","zdyyxy26","T2321005"],"pubmed_authors":["Liu Z","Yu C","Qin J","Wang D","Zhang LZ","Zhang L","Teng GJ","Feng LZ","Yang WH"],"additional_accession":[]},"is_claimable":false,"name":"Arginine-Loaded Nano-Calcium-Phosphate-Stabilized Lipiodol Pickering Emulsions Potentiates Transarterial Embolization-Immunotherapy.","description":"Transarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water-in-oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L-arginine (L-Arg), which is known for its ability to modulate T-cell metabolism. The obtained L-Arg-loaded CaP-stabilized lipiodol Pickering emulsion (L-Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also en","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-25T17:49:32.525Z","creation":"2025-04-06T06:27:10.789Z"},"accession":"S-EPMC11809372","cross_references":{"pubmed":["39680010"],"doi":["10.1002/advs.202410484"]}}