biostudies-literatureWang DResearch Personnel Cultivation Programme of Zhongda Hospital Southeast UniversityZhongda Hospital Affiliated to Southeast University, Jiangsu Province High-level Hospital Pairing Assistance Construction FundsCollaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, and Nanjing Life Health Science and Technology ProjectNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationNational Key Research and Development ProgramJiangsu Provincial Medical Innovation CenterPostdoctoral Fellowship Program of CPSFe2410484https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809372biostudies-literatureUnknown12(6)Transarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water-in-oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L-arginine (L-Arg), which is known for its ability to modulate T-cell metabolism. The obtained L-Arg-loaded CaP-stabilized lipiodol Pickering emulsion (L-Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also enAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Arginine-Loaded Nano-Calcium-Phosphate-Stabilized Lipiodol Pickering Emulsions Potentiates Transarterial Embolization-Immunotherapy.PMC118093722018YFA070410061821002CXZX20221952032008CZXM-GSP-RC81BX202300682024M750454823023302024M750452821300602018YFA070410482402408202205045zdyyxy26T2321005Liu ZYu CQin JWang DZhang LZZhang LTeng GJFeng LZYang WHfalseArginine-Loaded Nano-Calcium-Phosphate-Stabilized Lipiodol Pickering Emulsions Potentiates Transarterial Embolization-Immunotherapy.Transarterial chemoembolization (TACE) continues to stand as a primary option for treating unresectable hepatocellular carcinoma (HCC). However, the increased tumor hypoxia and acidification will lead to the immunosuppressive tumor microenvironment (TME) featuring exhausted T cells, limiting the effectiveness of subsequent therapies following TACE. Herein, a stable water-in-oil lipiodol Pickering emulsion by employing calcium phosphate nanoparticles (CaP NPs) as stabilizers is developed and used to encapsulate L-arginine (L-Arg), which is known for its ability to modulate T-cell metabolism. The obtained L-Arg-loaded CaP-stabilized lipiodol Pickering emulsion (L-Arg@CaPL) with great emulsion stability can not only neutralize the tumor acidity via reaction of CaP NPs with protons but also en2025-01-01T00:00:00Z2025 Feb2025-04-25T17:49:32.525Z2025-04-06T06:27:10.789ZS-EPMC118093723968001010.1002/advs.202410484