{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu H"],"funding":["HFIPS Director's Fund","National Natural Science Foundation of China","Anhui Provincial Natural Science Foundation"],"pagination":["e2413475"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809397"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(6)"],"pubmed_abstract":["Cyclohexanone oxime, a critical precursor for nylon-6 production, is traditionally synthesized via the hydroxylamine method under industrial harsh conditions. Here is present a one-step electrochemical integrated approach for the efficient production of cyclohexanone oxime under ambient conditions. This approach employed the coupling of in situ electro-synthesized H<sub>2</sub>O<sub>2</sub> over a cobalt (Co)-based electrocatalyst with the titanium silicate-1 (TS-1) heterogeneous catalyst to achieve the cyclohexanone ammoximation process. The cathode electrocatalyst is consisted of atomically dispersed Co sites and small Co nanoparticles co-anchored on carboxylic multi-walled carbon nanotubes (CoSAs/SNPs-OCNTs), which delivered superior electrocatalytic activity toward the two-electron oxygen reduction reaction (2e<sup>-</sup> ORR) with high-efficient H<sub>2</sub>O<sub>2</sub> production in 0.1 m sodium phosphate (NaPi). Theoretical calculations revealed that the introduction of Co nanoparticles effectively optimized the binding strength of <sup>*</sup>OOH species on Co atomic sites, thus facilitating the 2e<sup>-</sup> ORR. The subsequent tandem catalytic system achieved a high cyclohexanone conversion of 71.7% ± 1.1% with a cyclohexanone oxime selectivity of 70.3% ± 0.6%. In this system, the TS-1 catalyst effectively captured the <sup>*</sup>OOH intermediate and activated the in situ generated H<sub>2</sub>O<sub>2</sub> to form Ti-OOH species, which promoted the formation of hydroxylamine and thereby enhanced the oxime production performance."],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Ambient Synthesis of Cyclohexanone Oxime via In Situ Produced Hydrogen Peroxide over Cobalt-Based Electrocatalyst."],"pmcid":["PMC11809397"],"funding_grant_id":["52472113","2408085MB021","YZJJ-GGZX-2022-01"],"pubmed_authors":["Xu M","Zhang Y","Zhang X","Zhang H","Jin M","Wang G","Xu H","Zhang S"],"additional_accession":[]},"is_claimable":false,"name":"Ambient Synthesis of Cyclohexanone Oxime via In Situ Produced Hydrogen Peroxide over Cobalt-Based Electrocatalyst.","description":"Cyclohexanone oxime, a critical precursor for nylon-6 production, is traditionally synthesized via the hydroxylamine method under industrial harsh conditions. Here is present a one-step electrochemical integrated approach for the efficient production of cyclohexanone oxime under ambient conditions. This approach employed the coupling of in situ electro-synthesized H<sub>2</sub>O<sub>2</sub> over a cobalt (Co)-based electrocatalyst with the titanium silicate-1 (TS-1) heterogeneous catalyst to achieve the cyclohexanone ammoximation process. The cathode electrocatalyst is consisted of atomically dispersed Co sites and small Co nanoparticles co-anchored on carboxylic multi-walled carbon nanotubes (CoSAs/SNPs-OCNTs), which delivered superior electrocatalytic activity toward the two-electron oxygen reduction reaction (2e<sup>-</sup> ORR) with high-efficient H<sub>2</sub>O<sub>2</sub> production in 0.1 m sodium phosphate (NaPi). Theoretical calculations revealed that the introduction of Co nanoparticles effectively optimized the binding strength of <sup>*</sup>OOH species on Co atomic sites, thus facilitating the 2e<sup>-</sup> ORR. The subsequent tandem catalytic system achieved a high cyclohexanone conversion of 71.7% ± 1.1% with a cyclohexanone oxime selectivity of 70.3% ± 0.6%. In this system, the TS-1 catalyst effectively captured the <sup>*</sup>OOH intermediate and activated the in situ generated H<sub>2</sub>O<sub>2</sub> to form Ti-OOH species, which promoted the formation of hydroxylamine and thereby enhanced the oxime production performance.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-25T17:55:10.672Z","creation":"2025-04-25T17:55:10.672Z"},"accession":"S-EPMC11809397","cross_references":{"pubmed":["39686758"],"doi":["10.1002/advs.202413475"]}}