{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Amaru R"],"pubmed_abstract":["<h4>Background</h4>Bolivian Andean Aymara highlanders, living at 4,000 m for 14,000 years, have evolved genetic adaptations to hypoxia. These include <i>EGLN1</i> encoding prolyl hydroxylase 2 (PHD2), a regulator of transferrin transcription. Transferrin level increases in hypoxia and iron deficiency. Contrasting reports indicate that elevated transferrin is associated with experimentally induced thrombosis in mice undergoing short-stay at high altitude, but with decreased thrombosis in a congenital disorder of hypoxia-sensing.<h4>Methods</h4>A retrospective study was conducted in people living at high altitude (3,650 - 4,150 m). We analyzed serum transferrin concentration and thrombosis history in Aymara patients with high-altitude erythrocytosis (n = 149, median age 55 years, female gend"],"journal":["Journal of hematology"],"pagination":["20-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809596"],"repository":["biostudies-literature"],"pubmed_title":["Increased Transferrin Concentrations Are Not Associated With Thrombosis in People Living at High Altitude."],"pmcid":["PMC11809596"],"pubmed_authors":["Gordeuk VR","Carrasco M","Mancilla E","Prchal J","Zhang X","Ganz T","Paton D","Amaru R"],"additional_accession":[]},"is_claimable":false,"name":"Increased Transferrin Concentrations Are Not Associated With Thrombosis in People Living at High Altitude.","description":"<h4>Background</h4>Bolivian Andean Aymara highlanders, living at 4,000 m for 14,000 years, have evolved genetic adaptations to hypoxia. These include <i>EGLN1</i> encoding prolyl hydroxylase 2 (PHD2), a regulator of transferrin transcription. Transferrin level increases in hypoxia and iron deficiency. Contrasting reports indicate that elevated transferrin is associated with experimentally induced thrombosis in mice undergoing short-stay at high altitude, but with decreased thrombosis in a congenital disorder of hypoxia-sensing.<h4>Methods</h4>A retrospective study was conducted in people living at high altitude (3,650 - 4,150 m). We analyzed serum transferrin concentration and thrombosis history in Aymara patients with high-altitude erythrocytosis (n = 149, median age 55 years, female gend","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-25T17:47:06.319Z","creation":"2025-04-25T17:47:06.319Z"},"accession":"S-EPMC11809596","cross_references":{"pubmed":["39935698"],"doi":["10.14740/jh1388"]}}