{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maddock RJ"],"funding":["NICHD NIH HHS","Intellectual and Developmental Disabilities Research Center, School of Medicine, Washington University in St. Louis","NCRR NIH HHS","NIMH NIH HHS","Yerkes National Primate Research Center, Emory University","National Institute of Mental Health","University of California, Davis","National Institute of Child Health and Human Development"],"pagination":["280-290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809764"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["121"],"pubmed_abstract":["Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester. Brain metabolites in these animals were compared to offspring of dams that received saline (n = 10) or no injection (n = 4). N-acetylaspartate (NAA), glutamate, c"],"journal":["Brain, behavior, and immunity"],"pubmed_title":["Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation."],"pmcid":["PMC11809764"],"funding_grant_id":["RR00169","P50 HD103526","P50 MH106438","P51 RR000169","T32MH073124","P50HD103526","T32 MH073124","P50MH106438"],"pubmed_authors":["Schumann CD","Van de Water J","Maddock RJ","Kimberley McAllister A","Hogrefe CE","Lesh TA","Bauman MD","Bennett J","Styner MA","Carter CS","Tanase C","Amaral DG","Vlasova RM","Ryan AM","Chen S","Murai T","Geschwind DH","Iosif AM"],"additional_accession":[]},"is_claimable":false,"name":"Altered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation.","description":"Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester. Brain metabolites in these animals were compared to offspring of dams that received saline (n = 10) or no injection (n = 4). N-acetylaspartate (NAA), glutamate, c","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-04T02:39:09.614Z","creation":"2025-04-04T02:39:09.614Z"},"accession":"S-EPMC11809764","cross_references":{"pubmed":["39032543"],"doi":["10.1016/j.bbi.2024.07.011"]}}