biostudies-literatureMaddock RJNICHD NIH HHSIntellectual and Developmental Disabilities Research Center, School of Medicine, Washington University in St. LouisNCRR NIH HHSNIMH NIH HHSYerkes National Primate Research Center, Emory UniversityNational Institute of Mental HealthUniversity of California, DavisNational Institute of Child Health and Human Development280-290https://www.ebi.ac.uk/biostudies/studies/S-EPMC11809764biostudies-literatureUnknown121Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester. Brain metabolites in these animals were compared to offspring of dams that received saline (n = 10) or no injection (n = 4). N-acetylaspartate (NAA), glutamate, cBrain, behavior, and immunityAltered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation.PMC11809764RR00169P50 HD103526P50 MH106438P51 RR000169T32MH073124P50HD103526T32 MH073124P50MH106438Schumann CDVan de Water JMaddock RJKimberley McAllister AHogrefe CELesh TABauman MDBennett JStyner MACarter CSTanase CAmaral DGVlasova RMRyan AMChen SMurai TGeschwind DHIosif AMfalseAltered brain metabolites in male nonhuman primate offspring exposed to maternal immune activation.Converging data show that exposure to maternal immune activation (MIA) in utero alters brain development in animals and increases the risk of neurodevelopmental disorders in humans. A recently developed non-human primate MIA model affords opportunities for studies with uniquely strong translational relevance to human neurodevelopment. The current longitudinal study used 1H-MRS to investigate the developmental trajectory of prefrontal cortex metabolites in male rhesus monkey offspring of dams (n = 14) exposed to a modified form of the inflammatory viral mimic, polyinosinic:polycytidylic acid (Poly IC), in the late first trimester. Brain metabolites in these animals were compared to offspring of dams that received saline (n = 10) or no injection (n = 4). N-acetylaspartate (NAA), glutamate, c2024-01-01T00:00:00Z2024 Oct2025-04-04T02:39:09.614Z2025-04-04T02:39:09.614ZS-EPMC118097643903254310.1016/j.bbi.2024.07.011