{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hui H"],"funding":["Henan Province Key Subjects of Medicine","Medical Science and Technology Research Project of Henan Province"],"pagination":["5246"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11822014"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Thioredoxin Related Transmembrane Protein 1 (TMX1) encodes a thiol-disulfide oxidoreductase and regulates cleavage, formation, or isomerization of disulfide bonds among cysteine residues in proteins. Using bioinformatic analysis, we firstly prove TMX1 is significantly upregulated in lower-grade gliomas (LGGs) and associated with poor prognosis of LGG patients. Besides, it's also highly expressed in higher WHO grade, 1p/19q non-co-deleted and isocitrate dehydrogenase (IDH) wildtype LGGs, thus we established a TMX1-based nomogram model, which exhibits a strong and stable predictive ability in the prognosis of LGG patients. Then, we also noticed that TMX1 was significantly associated with the immune cell infiltrations in LGGs, especially in B cell, CD8<sup>+</sup> T cell, CD4<sup>+</sup>T cel"],"journal":["Scientific reports"],"pubmed_title":["Thioredoxin related transmembrane protein 1acts as a prognostic indictor and promotes proliferation and TMZ resistance of lower-grade glioma."],"pmcid":["PMC11822014"],"funding_grant_id":["NA","LHGJ20230526"],"pubmed_authors":["Pei S","Wang P","Shang J","Deng Z","Hui H","Zhou W","Zhou F","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Thioredoxin related transmembrane protein 1acts as a prognostic indictor and promotes proliferation and TMZ resistance of lower-grade glioma.","description":"Thioredoxin Related Transmembrane Protein 1 (TMX1) encodes a thiol-disulfide oxidoreductase and regulates cleavage, formation, or isomerization of disulfide bonds among cysteine residues in proteins. Using bioinformatic analysis, we firstly prove TMX1 is significantly upregulated in lower-grade gliomas (LGGs) and associated with poor prognosis of LGG patients. Besides, it's also highly expressed in higher WHO grade, 1p/19q non-co-deleted and isocitrate dehydrogenase (IDH) wildtype LGGs, thus we established a TMX1-based nomogram model, which exhibits a strong and stable predictive ability in the prognosis of LGG patients. Then, we also noticed that TMX1 was significantly associated with the immune cell infiltrations in LGGs, especially in B cell, CD8<sup>+</sup> T cell, CD4<sup>+</sup>T cel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T21:14:02.875Z","creation":"2025-04-06T10:36:09.696Z"},"accession":"S-EPMC11822014","cross_references":{"pubmed":["39939413"],"doi":["10.1038/s41598-025-89908-y"]}}