{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xue B"],"funding":["Excellent Youth Foundation of Henan Scientific Committee","National Natural Science Foundation of China","He'nan Provincial Science and Technology Research Project","Program for Innovative Research Team (in Science and Technology) in University of Henan Province"],"pagination":["63"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11823085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["Background
The global rise in multidrug-resistant bacteria has significantly undermined the efficacy of traditional antibiotics. Multidrug-resistant Streptococcus suis (S. suis), a pathogen capable of infecting pigs and humans, has been identified as a critical threat, causing severe meningitis and rapid mortality. In response, researchers have increasingly focused on herbal compounds as non-traditional antimicrobial agents, which can inhibit bacterial growth while minimizing the risk of resistance development. This study investigates the mechanism through which andrographolide (AP) restores the susceptibility of S. suis to aminoglycoside antibiotics.Methods
The intracellular ΔpH in S. suis was assessed using the 2',7' -bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCC"],"journal":["BMC veterinary research"],"pubmed_title":["Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force."],"pmcid":["PMC11823085"],"funding_grant_id":["232102110095","32172852","222300420005","24IRTSTHN033"],"pubmed_authors":["Li H","Xue B","Yi L","Wang Y","Quan Y","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Andrographolide reverses the susceptibility of Streptococcus suis to aminoglycoside antibiotics by proton motive force.","description":"Background
The global rise in multidrug-resistant bacteria has significantly undermined the efficacy of traditional antibiotics. Multidrug-resistant Streptococcus suis (S. suis), a pathogen capable of infecting pigs and humans, has been identified as a critical threat, causing severe meningitis and rapid mortality. In response, researchers have increasingly focused on herbal compounds as non-traditional antimicrobial agents, which can inhibit bacterial growth while minimizing the risk of resistance development. This study investigates the mechanism through which andrographolide (AP) restores the susceptibility of S. suis to aminoglycoside antibiotics.Methods
The intracellular ΔpH in S. suis was assessed using the 2',7' -bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCC","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-26T16:26:54.832Z","creation":"2025-04-06T15:14:22.121Z"},"accession":"S-EPMC11823085","cross_references":{"pubmed":["39939878"],"doi":["10.1186/s12917-024-04430-z"]}}