{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Fernandez-Albarral JA"],"pubmed_abstract":["Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor in several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) is crucial for brain water homeostasis, with Aqp4 knockout mice showing sporadic ventriculomegaly and increased brain water content. Kinase D interacting substrate of 220 kDa (Kidins220), a transmembrane protein involved in neuronal survival, synaptic activity and neurogenesis, controls AQP4 levels in ependymocytes and brain astrocytes. Indeed, Kidins220 deficiency in mice leads to hydrocephalus by downregulating VPS35, a key component of the retromer complex, and targeting AQP4 to lysosomal degradation. Importantly, the ependymal barrier of idiopathic norma"],"journal":["Fluids and barriers of the CNS"],"pagination":["16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11823095"],"repository":["biostudies-literature"],"pubmed_title":["Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival."],"pmcid":["PMC11823095"],"pubmed_authors":["Pajuelo LSM","Elvira-Hurtado L","Salazar JJ","Sanz M","Sanchez-Puebla L","Lopez-Menendez C","Lopez-Cuenca I","Sanchez-Carralero MP","Iglesias T","Salobrar-Garcia E","Ramirez JM","Fernandez-Albarral JA","de Hoz R","Matamoros JA","Simon-Garcia A","Ramirez AI"],"additional_accession":[]},"is_claimable":false,"name":"Kidins220-deficient hydrocephalus mice exhibit altered glial phenotypes and AQP4 differential regulation in the retina and optic nerve, with preserved retinal ganglion cell survival.","description":"Hydrocephalus, characterized by ventriculomegaly due to cerebrospinal fluid accumulation in the cerebral ventricles, is a co-morbidity factor in several neurodevelopmental, psychiatric and neurodegenerative diseases. Aquaporin-4 (AQP4) is crucial for brain water homeostasis, with Aqp4 knockout mice showing sporadic ventriculomegaly and increased brain water content. Kinase D interacting substrate of 220 kDa (Kidins220), a transmembrane protein involved in neuronal survival, synaptic activity and neurogenesis, controls AQP4 levels in ependymocytes and brain astrocytes. Indeed, Kidins220 deficiency in mice leads to hydrocephalus by downregulating VPS35, a key component of the retromer complex, and targeting AQP4 to lysosomal degradation. Importantly, the ependymal barrier of idiopathic norma","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-25T17:42:55.183Z","creation":"2025-04-06T06:48:17.459Z"},"accession":"S-EPMC11823095","cross_references":{"pubmed":["39939990"],"doi":["10.1186/s12987-025-00626-z"]}}