{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petrozziello T"],"funding":["NIA NIH HHS","NINDS NIH HHS"],"pagination":["267-281"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11823699"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["<h4>Background</h4>To date, it is still controversial whether tau phosphorylation plays a role in Huntington's disease (HD), as previous studies demonstrated either no alterations or increases in phosphorylated tau (pTau) in HD postmortem brain and mouse models.<h4>Objective</h4>The goal of this study was to determine whether total tau and pTau levels are altered in HD.<h4>Methods</h4>Immunohistochemistry, cellular fractionations, and western blots were used to measure total tau and pTau levels in a large cohort of HD and control postmortem prefrontal cortex (PFC). Furthermore, western blots were performed to assess tau, and pTau levels in HD and control isogenic embryonic stem cell (ESC)-derived cortical neurons and neuronal stem cells (NSCs). Similarly, western blots were used to assess "],"journal":["Journal of Huntington's disease"],"pubmed_title":["Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex."],"pmcid":["PMC11823699"],"funding_grant_id":["R01 NS126420","P30 AG062421"],"pubmed_authors":["Connors TR","Wu M","Quinn JP","Pouladi MA","Huntress SS","DiFiglia M","Sunderesh SR","Rosas HD","Boudi A","Liu S","Petrozziello T","Mills AN","Mouro Pinto R","Mahmood F","Sadri-Vakili G","Castillo-Torres AL","Auger CA","Arnold SE","Kim SE","Hyman BT","Kivisakk P","Kegel-Gleason K","Sapp E"],"additional_accession":[]},"is_claimable":false,"name":"Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex.","description":"<h4>Background</h4>To date, it is still controversial whether tau phosphorylation plays a role in Huntington's disease (HD), as previous studies demonstrated either no alterations or increases in phosphorylated tau (pTau) in HD postmortem brain and mouse models.<h4>Objective</h4>The goal of this study was to determine whether total tau and pTau levels are altered in HD.<h4>Methods</h4>Immunohistochemistry, cellular fractionations, and western blots were used to measure total tau and pTau levels in a large cohort of HD and control postmortem prefrontal cortex (PFC). Furthermore, western blots were performed to assess tau, and pTau levels in HD and control isogenic embryonic stem cell (ESC)-derived cortical neurons and neuronal stem cells (NSCs). Similarly, western blots were used to assess ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-05T09:39:26.604Z","creation":"2025-04-05T09:39:26.604Z"},"accession":"S-EPMC11823699","cross_references":{"pubmed":["37694372"],"doi":["10.3233/JHD-230588","10.3233/jhd-230588"]}}