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APR after preoperative CRT was associated with a significantly worse overall survival (p = 0.0056), disease-free survival (p < 0.0001) and local recurrence rate (p = 0"],"journal":["Scientific reports"],"pagination":["5401"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11825916"],"repository":["biostudies-literature"],"pubmed_title":["Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial."],"pmcid":["PMC11825916"],"pubmed_authors":["Gaedcke J","Wachter S","Kneist W","Wulf D","Hoffken K","Harloff M","Vierling P","Schulz C","Mergen E","Kohne CH","Kirchner T","Radtke A","Stark U","Hempel D","Freund U","Ruhlmann F","Rosskopf B","Heiss MM","Hofler H","Herrmann T","Herrmann M","Steder M","Vogel C","Stadler J","Hahn M","Kosmehl H","Heimbucher J","Kreis M","Horn D","Godderz W","Ebeling M","Ritter U","Gnann W","Ruffert K","Ziegler KW","Kuhlgatz J","Sitskaia X","German 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M"],"additional_accession":[]},"is_claimable":false,"name":"Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial.","description":"Low anterior resection (LAR) and abdominoperineal resection (APR) are the two main surgical procedures after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. APR is associated with poorer prognosis; however existing data do not consider intensified CRT (5-Fluorouracil (5-FU)/Oxaliplatin + radiation) protocols. Clinicopathological data of patients treated with APR and LAR from the CAO/ARO/AIO-04 trial were analysed in terms of prognostic parameters and quality of life (QoL). Based on higher response rate after intensified CRT, subgroup analyses were performed. Data from n = 1173 patients were assessed. APR after preoperative CRT was associated with a significantly worse overall survival (p = 0.0056), disease-free survival (p < 0.0001) and local recurrence rate (p = 0","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-02T02:06:52.471Z","creation":"2025-04-04T02:12:47.476Z"},"accession":"S-EPMC11825916","cross_references":{"pubmed":["39948076"],"doi":["10.1038/s41598-024-83105-z"]}}