biostudies-literatureUnknown15(1)Gaedcke JLow anterior resection (LAR) and abdominoperineal resection (APR) are the two main surgical procedures after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. APR is associated with poorer prognosis; however existing data do not consider intensified CRT (5-Fluorouracil (5-FU)/Oxaliplatin + radiation) protocols. Clinicopathological data of patients treated with APR and LAR from the CAO/ARO/AIO-04 trial were analysed in terms of prognostic parameters and quality of life (QoL). Based on higher response rate after intensified CRT, subgroup analyses were performed. Data from n = 1173 patients were assessed. APR after preoperative CRT was associated with a significantly worse overall survival (p = 0.0056), disease-free survival (p < 0.0001) and local recurrence rate (p = 0Scientific reports5401https://www.ebi.ac.uk/biostudies/studies/S-EPMC11825916biostudies-literaturePrognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial.PMC11825916Gaedcke JWachter SKneist WWulf DHoffken KHarloff MVierling PSchulz CMergen EKohne CHKirchner TRadtke AStark UHempel DFreund URuhlmann FRosskopf BHeiss MMHofler HHerrmann THerrmann MSteder MVogel CStadler JHahn MKosmehl HHeimbucher JKreis MHorn DGodderz WEbeling MRitter UGnann WRuffert KZiegler KWKuhlgatz JSitskaia XGerman Rectal Cancer Study GroupEidt SStrobel GFSeraphin JHorn WDiebold KStaar SGnann HNiehaus JMuller-Hermelink HKSchorp TBittrich ASchubert KHFein MZeller WSchwarz BGrotschla THeider KMHeckmann MELahmer GFietkau RHorst ERosler EArps HFreier WRau 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GWilhelm TOckert DJany BHubrich KKeilholz LTeyssen SKeymer RReichenbach GTzonos SWilhelm MWirsching Ade Weerth AMatnjani GFuzesi LBlum IWillborn KCLink KHBlum MHuff HHartmann AWoidy LSchlag REhlers IWeber BKrull AAuberger TMerkle NBudde RWierecky JDolken GSido BPreiss ADurk HWartenberg SLatz DJakob ABartsch DSchuler AKlar EBeckurts KTEOtt RPrott FJCaselitz JBurrig KFPommerenke FViebahn RStaib LBechstein WOKubin TWAltendorf-Hofmann ASteinbrecher CFellbaum CNusse TSajdova TDietrich CHogel BKronawitter USauer RRuelfs CTatsis PFurst ADang-Lieu BBeck CRaub MAckermann DKonig BFrilling AEypasch EDreßler WMomm FGhilescu VFischer GSteiner BArndt MIllerhaus GLangenscheidt PHellfritzsch HKrebs BBonhag HDornoff WOmlor GKempf BKnipp HStrater JLutterbach JSeipelt GNizze HBuckisch-Urbanke EStrumberg DGonner URuff WMenig MStallmach AHellinger AStohr GSchieder HWeigang-Kohler KGokkurt EBetzler MKirkpatrick CJWerner MRoder JSure MLindemann FJaspersen DJung CBartelt SGuntheroth SMose SGulzad NGosenheimer RWillich NRingel RSchwenger PRudiger KDJung MLindemann WPfluger KHLerchenmuller CSohm MBerns TSchroder JKnoll MKrammer-Steiner BRaab RKerkhoff AOpitz OFisseler-Eckhoff AKost SRudykina GDussel APDietze LOpitz BKolbl OHostege ABottcher HDHirsch FPiso PMoller PBendel MSchlemminger RHeuche KLuttges JKleimann ERaab MRosler HPPothmann MFolprecht GKraft KHolzinger HWittkowsky GHeil GRothmund MDienes HPBremer AMichal WHinrichs BBendel VMoll RKoebe JGMihaljevic Avon Weikersthal LFRexrodt PKimmig BGermer CHertenstein BStinner BGrehl SOppenkowski RBrockmann MStengel BGrimm HSchonberger BTietze LDetken SSchorcht JScheruhn MEinsele HKrings WLocken ADahm HHBarkhausen KSiebler JWunsch PEbner VOtt MHoffmanns HHartung EReiter CFietz TSchmidberger HSchilcher FSeegenschmiedt MHSchmid KWSchoppmeyer KLainka MfalsePrognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial.Low anterior resection (LAR) and abdominoperineal resection (APR) are the two main surgical procedures after preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer. APR is associated with poorer prognosis; however existing data do not consider intensified CRT (5-Fluorouracil (5-FU)/Oxaliplatin + radiation) protocols. Clinicopathological data of patients treated with APR and LAR from the CAO/ARO/AIO-04 trial were analysed in terms of prognostic parameters and quality of life (QoL). Based on higher response rate after intensified CRT, subgroup analyses were performed. Data from n = 1173 patients were assessed. APR after preoperative CRT was associated with a significantly worse overall survival (p = 0.0056), disease-free survival (p < 0.0001) and local recurrence rate (p = 02025-01-01T00:00:00Z2025 Feb2026-06-02T02:06:52.471Z2025-04-04T02:12:47.476ZS-EPMC118259163994807610.1038/s41598-024-83105-z