{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fang X"],"funding":["Foundation of Shanghai Municipal Health Commission","Investigator Initiated Research Projects","Key Discipline and Special Disease Construction Project of Huadong Hospital","National Natural Science Foundation of China","Beijing Natural Science Foundation"],"pagination":["e14525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11826331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(2)"],"pubmed_abstract":["

Introduction

Idiopathic normal pressure hydrocephalus (iNPH), a condition that primarily affects the elderly, has an unclear prevalence rate in China.

Methods

A cross-sectional survey involving 1491 seniors aged 60 and above in Shanghai was conducted. Clinical symptoms and brain imaging data were collected for the diagnosis of suboptimal probable iNPH (s-probable iNPH). The crude prevalence was calculated and the estimated prevalence was inferred.

Results

The crude prevalence of s-probable iNPH was 3.09% and 2.62% respectively, using DESH score ≥6 and Radscale score ≥7 as the primary imaging diagnostic criteria. The estimated prevalence of Shanghai was 2.59% among people over 60 years old and it rose to 7.99% among people aged over 90, and it was estimated that 134,152 and 11,708, respectively, had s-probable iNPH among the corresponding age group.

Discussion

The prevalence of s-probable iNPH fluctuates based on the radiological scoring systems and the defined thresholds employed, and it tends to rise with advancing age.

Highlights

**Significant Prevalence**: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90-99 years and centenarians. **Diagnostic Approach**: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH. **Gender Disparity**: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups. **Clinical Implications**: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances. **Public Health Impact**: The estimated number of s-probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Prevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population-based observational study."],"pmcid":["PMC11826331"],"funding_grant_id":["H2022003","20184Y0098","201740003","202340152","7202237","81771816","ZDZB2220"],"pubmed_authors":["Fang X","Li S","Hu J","Xing Y","Mao R","Liu C","Zhang L","Xu X","Tang F","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"Prevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population-based observational study.","description":"

Introduction

Idiopathic normal pressure hydrocephalus (iNPH), a condition that primarily affects the elderly, has an unclear prevalence rate in China.

Methods

A cross-sectional survey involving 1491 seniors aged 60 and above in Shanghai was conducted. Clinical symptoms and brain imaging data were collected for the diagnosis of suboptimal probable iNPH (s-probable iNPH). The crude prevalence was calculated and the estimated prevalence was inferred.

Results

The crude prevalence of s-probable iNPH was 3.09% and 2.62% respectively, using DESH score ≥6 and Radscale score ≥7 as the primary imaging diagnostic criteria. The estimated prevalence of Shanghai was 2.59% among people over 60 years old and it rose to 7.99% among people aged over 90, and it was estimated that 134,152 and 11,708, respectively, had s-probable iNPH among the corresponding age group.

Discussion

The prevalence of s-probable iNPH fluctuates based on the radiological scoring systems and the defined thresholds employed, and it tends to rise with advancing age.

Highlights

**Significant Prevalence**: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90-99 years and centenarians. **Diagnostic Approach**: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH. **Gender Disparity**: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups. **Clinical Implications**: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances. **Public Health Impact**: The estimated number of s-probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T07:34:51.628Z","creation":"2025-04-04T07:34:51.628Z"},"accession":"S-EPMC11826331","cross_references":{"pubmed":["39950414"],"doi":["10.1002/alz.14525"]}}