biostudies-literatureFang XFoundation of Shanghai Municipal Health CommissionInvestigator Initiated Research ProjectsKey Discipline and Special Disease Construction Project of Huadong HospitalNational Natural Science Foundation of ChinaBeijing Natural Science Foundatione14525https://www.ebi.ac.uk/biostudies/studies/S-EPMC11826331biostudies-literatureUnknown21(2)<h4>Introduction</h4>Idiopathic normal pressure hydrocephalus (iNPH), a condition that primarily affects the elderly, has an unclear prevalence rate in China.<h4>Methods</h4>A cross-sectional survey involving 1491 seniors aged 60 and above in Shanghai was conducted. Clinical symptoms and brain imaging data were collected for the diagnosis of suboptimal probable iNPH (s-probable iNPH). The crude prevalence was calculated and the estimated prevalence was inferred.<h4>Results</h4>The crude prevalence of s-probable iNPH was 3.09% and 2.62% respectively, using DESH score ≥6 and Radscale score ≥7 as the primary imaging diagnostic criteria. The estimated prevalence of Shanghai was 2.59% among people over 60 years old and it rose to 7.99% among people aged over 90, and it was estimated that 134,152 and 11,708, respectively, had s-probable iNPH among the corresponding age group.<h4>Discussion</h4>The prevalence of s-probable iNPH fluctuates based on the radiological scoring systems and the defined thresholds employed, and it tends to rise with advancing age.<h4>Highlights</h4>^**Significant Prevalence^**: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90-99 years and centenarians. ^**Diagnostic Approach^**: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH. ^**Gender Disparity^**: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups. ^**Clinical Implications^**: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances. ^**Public Health Impact^**: The estimated number of s-probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population.Alzheimer's & dementia : the journal of the Alzheimer's AssociationPrevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population-based observational study.PMC11826331H202200320184Y0098201740003202340152720223781771816ZDZB2220Fang XLi SHu JXing YMao RLiu CZhang LXu XTang FDeng YfalsePrevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population-based observational study.<h4>Introduction</h4>Idiopathic normal pressure hydrocephalus (iNPH), a condition that primarily affects the elderly, has an unclear prevalence rate in China.<h4>Methods</h4>A cross-sectional survey involving 1491 seniors aged 60 and above in Shanghai was conducted. Clinical symptoms and brain imaging data were collected for the diagnosis of suboptimal probable iNPH (s-probable iNPH). The crude prevalence was calculated and the estimated prevalence was inferred.<h4>Results</h4>The crude prevalence of s-probable iNPH was 3.09% and 2.62% respectively, using DESH score ≥6 and Radscale score ≥7 as the primary imaging diagnostic criteria. The estimated prevalence of Shanghai was 2.59% among people over 60 years old and it rose to 7.99% among people aged over 90, and it was estimated that 134,152 and 11,708, respectively, had s-probable iNPH among the corresponding age group.<h4>Discussion</h4>The prevalence of s-probable iNPH fluctuates based on the radiological scoring systems and the defined thresholds employed, and it tends to rise with advancing age.<h4>Highlights</h4>^**Significant Prevalence^**: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90-99 years and centenarians. ^**Diagnostic Approach^**: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH. ^**Gender Disparity^**: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups. ^**Clinical Implications^**: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances. ^**Public Health Impact^**: The estimated number of s-probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population.2025-01-01T00:00:00Z2025 Feb2025-04-04T07:34:51.628Z2025-04-04T07:34:51.628ZS-EPMC118263313995041410.1002/alz.14525