{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goeckner BD"],"funding":["NINDS NIH HHS"],"pagination":["524-534"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11828682"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(3)"],"pubmed_abstract":["Introduction
Female athletes are underrepresented in concussion research, and few studies have investigated associations of ovarian hormones with concussion outcomes. This study explored associations of concussion with levels and variability of progesterone, estradiol, and their ratio (P/E) and examined relationships of hormone levels with clinical measures and recovery after concussion in CARE Consortium female athletes and cadets.Methods
Female participants enrolled ( n = 749) at pre-injury baseline. Participants with concussion (mean age, 19.34 yr; n = 130, 90 athletes, 40 nonathlete cadets) completed one or more visits at nonstandardized times of day: immediately post-injury, 24 h post-injury, upon initiating the return-to-play protocol (Init RTP), and 7 d following unr"],"journal":["Medicine and science in sports and exercise"],"pubmed_title":["Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets."],"pmcid":["PMC11828682"],"funding_grant_id":["R21 NS118169"],"pubmed_authors":["Goeckner BD","Broglio SP","Huber DL","CARE CONSORTIUM INVESTIGATORS","Gill JM","Master CL","Pasquina PF","Brett BL","Meier TB","McAllister TW","Harezlak J","VAN Bortel K","McCrea MA","Mannix R"],"additional_accession":[]},"is_claimable":false,"name":"Progesterone and Estradiol Levels Associated with Concussion and Clinical Outcomes and Recovery in Female Athletes and Cadets.","description":"Introduction
Female athletes are underrepresented in concussion research, and few studies have investigated associations of ovarian hormones with concussion outcomes. This study explored associations of concussion with levels and variability of progesterone, estradiol, and their ratio (P/E) and examined relationships of hormone levels with clinical measures and recovery after concussion in CARE Consortium female athletes and cadets.Methods
Female participants enrolled ( n = 749) at pre-injury baseline. Participants with concussion (mean age, 19.34 yr; n = 130, 90 athletes, 40 nonathlete cadets) completed one or more visits at nonstandardized times of day: immediately post-injury, 24 h post-injury, upon initiating the return-to-play protocol (Init RTP), and 7 d following unr","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-07-16T23:28:42.975Z","creation":"2026-07-12T03:11:16.604Z"},"accession":"S-EPMC11828682","cross_references":{"pubmed":["39501473"],"doi":["10.1249/mss.0000000000003591","10.1249/MSS.0000000000003591"]}}