{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Procter RJ"],"funding":["Institució Catalana de Recerca i Estudis Avançats","Engineering and Physical Sciences Research Council"],"pagination":["4718-4724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11831689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(11)"],"pubmed_abstract":["The catalytic activity of different classes of boron catalysts was studied in amidation reactions with 4-phenylbutylamine/benzoic acid, and with 2-aminopyridine/phenylacetic acid. Whilst a simple boronic acid catalyst showed high catalytic activity with the former substrates, it was completely inactive in the latter reaction. In contrast, a borate ester catalyst was able to mediate the amidation of both substrate pairs with moderate activity. By screening a range of borate esters we were able to identify a novel borate catalyst that shows high reactivity with a range of challenging carboxylic acids/amine pairs, enabling catalystic amidation reactions to be achieved effectively with these industrially relevant compounds. The reactions can be performed on multigram scale with high levels of "],"journal":["Chemical science"],"pubmed_title":["Borate-catalysed direct amidation reactions of coordinating substrates."],"pmcid":["PMC11831689"],"funding_grant_id":["EP/T030534/1","EP/T030666/1","EP/T030658/1","EP/T030488/1"],"pubmed_authors":["Procter RJ","Dumon AS","Whiting A","Alamillo-Ferrer C","Shabbir U","Rzepa HS","Bucar DK","Britton P","Sheppard TD","Bures J"],"additional_accession":[]},"is_claimable":false,"name":"Borate-catalysed direct amidation reactions of coordinating substrates.","description":"The catalytic activity of different classes of boron catalysts was studied in amidation reactions with 4-phenylbutylamine/benzoic acid, and with 2-aminopyridine/phenylacetic acid. Whilst a simple boronic acid catalyst showed high catalytic activity with the former substrates, it was completely inactive in the latter reaction. In contrast, a borate ester catalyst was able to mediate the amidation of both substrate pairs with moderate activity. By screening a range of borate esters we were able to identify a novel borate catalyst that shows high reactivity with a range of challenging carboxylic acids/amine pairs, enabling catalystic amidation reactions to be achieved effectively with these industrially relevant compounds. The reactions can be performed on multigram scale with high levels of ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2026-05-29T15:22:04.716Z","creation":"2025-04-04T02:12:43.084Z"},"accession":"S-EPMC11831689","cross_references":{"pubmed":["39968286"],"doi":["10.1039/d4sc07744j"]}}