{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(7)"],"submitter":["Kornsakulkarn J"],"pubmed_abstract":["Entomopathogenic fungi of the genus Hypocrella are known to produce bioactive compounds, in particular polyketides. Here, a chemical investigation of the entomopathogenic fungus <i>Hypocrella luteola</i> strain TBRC-BCC 76666 was performed to identify possible novel compounds indicated from HPLC and <sup>1</sup>H NMR spectra profiles of culture extracts. Eight novel compounds were isolated, including six new polyketides (1-6) and two other naturally occurring compounds (7-8), along with seven known compounds. The compound structures were established by spectroscopic analysis, the application of modified Mosher's method, and electronic circular dichroism. Compounds 1 and 5 were cytotoxic against both NCI-H187 and Vero cells (IC<sub>50</sub> = 9.9 and 58.9 μM, respectively), whereas compound 4 was active only against MCF-7 cells (IC<sub>50</sub> = 42.5 μM). Ascherxanthone B (9) exhibited antiproliferative activity against all cell lines tested (<i>Plasmodium falciparum</i>, mammalian, and fungal), with IC<sub>50</sub> and MIC values in the range 0.9-30.5 μM."],"journal":["RSC advances"],"pagination":["5234-5241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11831733"],"repository":["biostudies-literature"],"pubmed_title":["Bioactive polyketides from cultures of the entomopathogenic fungus <i>Hypocrella luteola</i> TBRC-BCC 76666."],"pmcid":["PMC11831733"],"pubmed_authors":["Thongpanchang C","Mongkolsamrit S","Kornsakulkarn J","Auncharoen P","Noisripoom W"],"additional_accession":[]},"is_claimable":false,"name":"Bioactive polyketides from cultures of the entomopathogenic fungus <i>Hypocrella luteola</i> TBRC-BCC 76666.","description":"Entomopathogenic fungi of the genus Hypocrella are known to produce bioactive compounds, in particular polyketides. Here, a chemical investigation of the entomopathogenic fungus <i>Hypocrella luteola</i> strain TBRC-BCC 76666 was performed to identify possible novel compounds indicated from HPLC and <sup>1</sup>H NMR spectra profiles of culture extracts. Eight novel compounds were isolated, including six new polyketides (1-6) and two other naturally occurring compounds (7-8), along with seven known compounds. The compound structures were established by spectroscopic analysis, the application of modified Mosher's method, and electronic circular dichroism. Compounds 1 and 5 were cytotoxic against both NCI-H187 and Vero cells (IC<sub>50</sub> = 9.9 and 58.9 μM, respectively), whereas compound 4 was active only against MCF-7 cells (IC<sub>50</sub> = 42.5 μM). Ascherxanthone B (9) exhibited antiproliferative activity against all cell lines tested (<i>Plasmodium falciparum</i>, mammalian, and fungal), with IC<sub>50</sub> and MIC values in the range 0.9-30.5 μM.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T10:30:13.99Z","creation":"2025-04-04T02:01:31.649Z"},"accession":"S-EPMC11831733","cross_references":{"pubmed":["39963459"],"doi":["10.1039/d4ra08431d"]}}