{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niu L"],"funding":["The Dunhill Medical Trust"],"pagination":["ziaf007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11831985"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["A wide range of specific microRNAs have been shown to have either positive or negative effects on osteoblast differentiation and function, with consequent changes in postnatal bone mass. A number of specific targets have been identified. We previously used CrispR-Cas9 to make a miR-455 null mouse, characterizing a behavioral phenotype with age. The current study identifies a bone phenotype, starting in younger animals. At 3 weeks of age, the miR-455 null mice (both male and female) display increased length of both long bones and vertebrae and, while this difference diminishes across 1 year, it remains significant. Increased bone formation in vivo is mirrored by an increase in osteogenesis from bone marrow-derived stem cells in vitro. This is accompanied by a decrease in osteoclastogenesis "],"journal":["JBMR plus"],"pubmed_title":["The microRNA-455 null mouse shows dysregulated bone turnover."],"pmcid":["PMC11831985"],"funding_grant_id":["R476/0516"],"pubmed_authors":["Hayman DJ","Young DA","Ersek A","Suelzu C","Niu L","Swingler TE","Barter MJ","Horwood N","Clark IM","Orriss IR"],"additional_accession":[]},"is_claimable":false,"name":"The microRNA-455 null mouse shows dysregulated bone turnover.","description":"A wide range of specific microRNAs have been shown to have either positive or negative effects on osteoblast differentiation and function, with consequent changes in postnatal bone mass. A number of specific targets have been identified. We previously used CrispR-Cas9 to make a miR-455 null mouse, characterizing a behavioral phenotype with age. The current study identifies a bone phenotype, starting in younger animals. At 3 weeks of age, the miR-455 null mice (both male and female) display increased length of both long bones and vertebrae and, while this difference diminishes across 1 year, it remains significant. Increased bone formation in vivo is mirrored by an increase in osteogenesis from bone marrow-derived stem cells in vitro. This is accompanied by a decrease in osteoclastogenesis ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Mar","modification":"2025-04-18T12:53:23.853Z","creation":"2025-04-04T00:51:45.677Z"},"accession":"S-EPMC11831985","cross_references":{"pubmed":["39963339"],"doi":["10.1093/jbmrpl/ziaf007"]}}