biostudies-literatureWang YNCI NIH HHSWellcome Trust273-282.e4https://www.ebi.ac.uk/biostudies/studies/S-EPMC11832009biostudies-literatureUnknown100(2)<h4>Background and aims</h4>No endoscopic scoring system has been established for immune-mediated colitis (IMC). This study aimed to establish such a system for IMC and explore its utility in guiding future selective immunosuppressive therapy (SIT) use compared to clinical symptoms.<h4>Methods</h4>This retrospective, international, 14-center study included 674 patients who developed IMC after immunotherapy and underwent endoscopic evaluation. Ten endoscopic features were selected by group consensus and assigned 1 point each to calculate an IMC endoscopic score (IMCES). IMCES cutoffs were chosen to maximize specificity for SIT use. This specificity was compared between IMCESs, and clinical symptoms were graded according to a standardized instrument.<h4>Results</h4>A total of 309 (45.8%) patGastrointestinal endoscopyNovel endoscopic scoring system for immune mediated colitis: a multicenter retrospective study of 674 patients.PMC11832009P30 CA016672P30 CA008748Lythgoe MWeppler AMSandhu SAlva AThomas AGrivas PPhilpott JOwen DHAbu-Sbeih HSleiman JTang TWang YPowell NDaniels EDiamantopoulos LArnold CAOlsson-Brown AJohnson DBCassol CIbraheim HDe Toni ENQiao WShatila MDougan MPhilipp ABShi CFaleck DPinato DJBuckle AHarris JWarner DEfalseNovel endoscopic scoring system for immune mediated colitis: a multicenter retrospective study of 674 patients.<h4>Background and aims</h4>No endoscopic scoring system has been established for immune-mediated colitis (IMC). This study aimed to establish such a system for IMC and explore its utility in guiding future selective immunosuppressive therapy (SIT) use compared to clinical symptoms.<h4>Methods</h4>This retrospective, international, 14-center study included 674 patients who developed IMC after immunotherapy and underwent endoscopic evaluation. Ten endoscopic features were selected by group consensus and assigned 1 point each to calculate an IMC endoscopic score (IMCES). IMCES cutoffs were chosen to maximize specificity for SIT use. This specificity was compared between IMCESs, and clinical symptoms were graded according to a standardized instrument.<h4>Results</h4>A total of 309 (45.8%) pat2024-01-01T00:00:00Z2024 Aug2026-03-18T13:22:26.618Z2025-08-18T09:53:58.171ZS-EPMC118320093827227610.1016/j.gie.2024.01.024