{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Becker WC"],"funding":["NCIPC CDC HHS","NCATS NIH HHS","NIDA NIH HHS","HSRD VA"],"pagination":["372-381"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11833656"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["185(4)"],"pubmed_abstract":["<h4>Importance</h4>Guidelines recommend dose reduction or discontinuation of long-term opioid therapy when harm outweighs benefit, but strategies to help patients do so are limited.<h4>Objective</h4>To test optionally switching to buprenorphine as a strategy for improving pain and reducing opioids among patients prescribed high-dose, full agonist long-term opioid therapy.<h4>Design, setting, and participants</h4>In this pragmatic, multisite, 12-month randomized clinical trial with masked outcome assessment, patients treated at Veterans Affairs primary care clinics were recruited from October 2017 to March 2021, with follow-up completed June 2022. Eligible patients had moderate to severe chronic pain despite high-dose opioid therapy (≥70 mg/d for at least 3 months). Patients were randomized"],"journal":["JAMA internal medicine"],"pubmed_title":["Buprenorphine, Pain, and Opioid Use in Patients Taking High-Dose Long-Term Opioids: A Randomized Clinical Trial."],"pmcid":["PMC11833656"],"funding_grant_id":["R01 CE003668","I01 HX003411","K23 DA047475","UL1 TR001863"],"pubmed_authors":["Aryal A","Patel A","Ugbo E","Carr M","Atkins D","Naylor J","Svabek K","Williams B","Tappainer C","Kross T","Carr T","Allen KD","Sloan J","Baskin J","Clay M","Glenn R","Sacra E","Anicich A","Walker J","Cutting A","Hawkins J","Huffman KF","McKissack M","Kats AM","Stoll S","Njau E","Thomas GR","Feuchs A","Sabet RF","Lorenzo J","Salameh H","Bohnert A","Sellinger J","Stoner T","Maloy P","Manuel J","Surginer B","Mundt J","Jones E","Bartlett S","Sculley M","Udouj R","Buonora M","Nichols A","Byerly S","Theis A","Givens C","Varughese SR","Miller E","Stoll J","Sumner JA","Okere J","Borowa D","Mapara P","Ankawi B","Hepton S","Craine M","Marcy B","Backe K","Reed J","VOICE Study Group","Barbosa M","Garvey C","Rouse R","Rutks I","Godwin K","Galvan R","Gosselin K","Grimm KF","Packard-Milam M","Wolfman A","Butler CA","Shah Barman M","Goldstein M","Bonchak J","Hyde S","Sides T","Wiener CH","Gayle S","Eichelsdoerfer E","Nelson A","DePesa N","Krebs EE","Pinsonnault J","Broderick D","Lewis M","Kerns R","Romano E","Marek L","Olney RL","Dadabayev A","Reddy S","Wilbur E","Strand M","Amundson E","Atkinson T","Purcell N","Thomas LC","Moon J","Olson J","Sadowski N","Sharpe P","Hall LM","Librodo S","Seal KH","Stevens S","Arnold S","Jensen A","Blehm R","Harden J","LaHaie E","Hidalgo N","Buesgens C","Morris H","Siver M","Feighner L","Roca H","Horowitz D","Johnson E","Lindsay D","Reznik TE","Hammett P","Sandbrink F","Brudvik E","Silver KE","Tiene K","Bartnik MK","Drexler K","Roberti A","Rozzero P","Coy WB","Bhushan S","Oakley JW","Painter JT","Bordanea M","Jacobson K","Taylor BC","Culver D","Erwin K","Frontera RA","Cariveau D","Edmond SN","Boesch N","Brown CB","Osler B","Daly D","Venkatraman S","Chandler M","Dike D","Heuermann B","McCamish N","Ofstad H","Tat C","Rezaei D","Becker WC","Westmoreland WC","Bowden M","Fike A","Gumidyala A","Hoffmann J","Holland-Deguire C","Lagisetty P","Duvall T","Rettmann N","Lively-Brindley L","Burch R","Bajpai S","Bolander S","Rosema T","Desmet P","Buchanan K","Kaiser B","Philippe M","Herynk A","Mason B","Seys R","Diokpa C","Booth K","Borsari B","Abelleira A","Schroeder A","Marcolivio K","Luciani L","Frank JW","Palyo S","Mixon AS","Barnett S","Noh M","Clarke K","Adams M","Hagedorn HJ","Drum-Oden A","Cervone D","Hudson T","Swanson G","Ellison J","Baller K","Escobedo C","DeRonne BM","Lelovic M","Woloszyn M","Mahal-Lichty J","Lahidji S","Sauve C","Wang G","Linden E","Watson K","Watson E","Denietolis AL","Schopmeyer KA","Nolan C","Hale A","Freeman JT","Huang A","Herbst E","Knutson R","Le G","Nugent S","Bangerter A","Kavathekar R","Osborne J","Hope K","Nazario M","Makris UE","Byrd G","Brooks K","Morasco BJ","Byrd C","Finetti T","Boening N","Graham S","Devlin A","Zanga J","Sewell K","Viera K","Britnell S","Dogra M","Kauzlarich K","Peter D","Ortolan V","Burton C","Son E","Carmody S","Degerstrom R","Baxley C","Nelson DB","Bair M","Ellifritz C","Franchina L","Marraffa R","Smith C","Nolan P","Bronars C","Zuniga S","Hunt NE","Robinson V","Eads FK","Lusk C","Campbell E","Hagerman C","Bloechl PP","Bolf M"],"additional_accession":[]},"is_claimable":false,"name":"Buprenorphine, Pain, and Opioid Use in Patients Taking High-Dose Long-Term Opioids: A Randomized Clinical Trial.","description":"<h4>Importance</h4>Guidelines recommend dose reduction or discontinuation of long-term opioid therapy when harm outweighs benefit, but strategies to help patients do so are limited.<h4>Objective</h4>To test optionally switching to buprenorphine as a strategy for improving pain and reducing opioids among patients prescribed high-dose, full agonist long-term opioid therapy.<h4>Design, setting, and participants</h4>In this pragmatic, multisite, 12-month randomized clinical trial with masked outcome assessment, patients treated at Veterans Affairs primary care clinics were recruited from October 2017 to March 2021, with follow-up completed June 2022. Eligible patients had moderate to severe chronic pain despite high-dose opioid therapy (≥70 mg/d for at least 3 months). Patients were randomized","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Apr","modification":"2026-07-15T22:11:57.235Z","creation":"2026-07-09T10:20:47.641Z"},"accession":"S-EPMC11833656","cross_references":{"pubmed":["39960730"],"doi":["10.1001/jamainternmed.2024.8361"]}}