{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liang X"],"funding":["Shenzhen Second People's Hospital Clinical Research Fund of Guangdong Province High-level Hospital Construction Project","Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties","Sanming Project of Medicine in Shenzhen"],"pagination":["170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11834603"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["<h4>Background</h4>Limited research has examined the potential association between triglyceride glucose-body mass index (TyG-BMI) and gestational diabetes mellitus (GDM). The objective of this investigation was to analyze this linkage and evaluate TyG-BMI's capability to predict GDM.<h4>Methods</h4>This research employed secondary data derived from a prospective cohort in South Korea, which included 588 pregnant women with singleton gestations, collected between November 2014 and July 2016. To investigate the connection between TyG-BMI and GDM, logistic regression and sensitivity analyses were performed. Furthermore, an analysis of receiver operating characteristics (ROC) was conducted to assess the prognostic accuracy of TyG-BMI in relation to GDM.<h4>Results</h4>The cohort exhibited a mean age of 32.07 ± 3.80 years, with 36 individuals (6.12%) manifesting GDM during the interval of 24 to 28 weeks of gestation. Following the adjustment for possible confounding variables, an increased TyG-BMI was associated with an elevated risk of GDM, as indicated by an odds ratio (OR) of 1.02 (95% CI: 1.01-1.04). Additionally, the area under the curve (AUC) for TyG-BMI's predictive performance was recorded at 0.7979 (0.7143-0.8814), with an optimal threshold established at 211.03, which resulted in a specificity of 86.23% and a sensitivity of 66.67%.<h4>Conclusions</h4>In this South Korean cohort, increased TyG-BMI during early pregnancy (10-14 weeks) was significantly associated with the onset of GDM (during pregnancy 24-28 weeks). TyG-BMI could be integrated into clinical practice as a complementary preliminary screening tool for detecting women who are at increased risk of GDM."],"journal":["BMC pregnancy and childbirth"],"pubmed_title":["Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study."],"pmcid":["PMC11834603"],"funding_grant_id":["No. SZGSP006","Grant No.20223357008, No.2023xgyj3357003","No. SZSM202211016"],"pubmed_authors":["Li X","Gui S","Xing Z","Li Y","Lai K","Liang X","Ren D"],"additional_accession":[]},"is_claimable":false,"name":"Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study.","description":"<h4>Background</h4>Limited research has examined the potential association between triglyceride glucose-body mass index (TyG-BMI) and gestational diabetes mellitus (GDM). The objective of this investigation was to analyze this linkage and evaluate TyG-BMI's capability to predict GDM.<h4>Methods</h4>This research employed secondary data derived from a prospective cohort in South Korea, which included 588 pregnant women with singleton gestations, collected between November 2014 and July 2016. To investigate the connection between TyG-BMI and GDM, logistic regression and sensitivity analyses were performed. Furthermore, an analysis of receiver operating characteristics (ROC) was conducted to assess the prognostic accuracy of TyG-BMI in relation to GDM.<h4>Results</h4>The cohort exhibited a mean age of 32.07 ± 3.80 years, with 36 individuals (6.12%) manifesting GDM during the interval of 24 to 28 weeks of gestation. Following the adjustment for possible confounding variables, an increased TyG-BMI was associated with an elevated risk of GDM, as indicated by an odds ratio (OR) of 1.02 (95% CI: 1.01-1.04). Additionally, the area under the curve (AUC) for TyG-BMI's predictive performance was recorded at 0.7979 (0.7143-0.8814), with an optimal threshold established at 211.03, which resulted in a specificity of 86.23% and a sensitivity of 66.67%.<h4>Conclusions</h4>In this South Korean cohort, increased TyG-BMI during early pregnancy (10-14 weeks) was significantly associated with the onset of GDM (during pregnancy 24-28 weeks). TyG-BMI could be integrated into clinical practice as a complementary preliminary screening tool for detecting women who are at increased risk of GDM.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-02T01:57:39.368Z","creation":"2025-04-04T02:12:42.668Z"},"accession":"S-EPMC11834603","cross_references":{"pubmed":["39962434"],"doi":["10.1186/s12884-025-07294-9"]}}