{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Roberts LB"],"funding":["The Royal Society","Research Councils UK","Wellcome Trust","UK Research and Innovation","Biotechnology and Biological Sciences Research Council"],"pagination":["39-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11835792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["The transcriptomic signatures that shape responses of innate lymphoid cells (ILCs) have been well characterised, however post-transcriptional mechanisms which regulate their development and activity remain poorly understood. We demonstrate that ILC groups of the intestinal lamina propria express mature forms of microRNA-142 (miR-142), an evolutionarily conserved microRNA family with several non-redundant regulatory roles within the immune system. Germline Mir142 deletion alters intestinal ILC compositions, resulting in the absence of T-bet<sup>+</sup> populations and significant defects in the cellularity and phenotypes of ILC3 subsets including CCR6<sup>+</sup> LTi-like ILC3s. These effects were associated with decreased pathology in an innate-immune cell driven model of colitis. Furtherm"],"journal":["Mucosal immunology"],"pubmed_title":["MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells."],"pmcid":["PMC11835792"],"funding_grant_id":["105644/Z/14/Z","BB/T014482/1"],"pubmed_authors":["Valpione S","Lee DCH","Lord GM","Tacho-Pinot R","Hepworth MR","Roberts LB","Neves JF","Howard JK"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells.","description":"The transcriptomic signatures that shape responses of innate lymphoid cells (ILCs) have been well characterised, however post-transcriptional mechanisms which regulate their development and activity remain poorly understood. We demonstrate that ILC groups of the intestinal lamina propria express mature forms of microRNA-142 (miR-142), an evolutionarily conserved microRNA family with several non-redundant regulatory roles within the immune system. Germline Mir142 deletion alters intestinal ILC compositions, resulting in the absence of T-bet<sup>+</sup> populations and significant defects in the cellularity and phenotypes of ILC3 subsets including CCR6<sup>+</sup> LTi-like ILC3s. These effects were associated with decreased pathology in an innate-immune cell driven model of colitis. Furtherm","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T00:31:31.901Z","creation":"2025-04-04T00:31:31.901Z"},"accession":"S-EPMC11835792","cross_references":{"pubmed":["39245145"],"doi":["10.1016/j.mucimm.2024.09.001"]}}