biostudies-literatureUnknown10Lei S<h4>Background</h4>Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have been equivocal. The optimal level of 25-hydroxyvitamin D (25[OH]D) remains controversial. Recommendations vary between societies. The lack of standardized assays also poses a challenge in interpreting available research data.<h4>Methods</h4>We systematically searched for articles in MEDLINE database through PubMed, which included meta-analysis, systematic reviews of randomized controlled trials (RCTs) and observational studies that assessed measurement, diagnosis and treatment about vitamin D deAnnals of joint1https://www.ebi.ac.uk/biostudies/studies/S-EPMC11836767biostudies-literatureExpert consensus on vitamin D in osteoporosis.PMC11836767Aleksova JBarzilay JILiu QWang LSong LWen JQiu SShen YZhao JTian JMac-Way FJi LDupuis MEMacIsaac RJXue YBenaiges DGallagher JCLi YMauricio DZhang ZZhang XXu SFang PYang RSommer APHan JPan LLei SLiu GfalseExpert consensus on vitamin D in osteoporosis.<h4>Background</h4>Adequate vitamin D is essential for maintaining optimal bone health, preventing and treating of osteoporosis. However, in recent years, large clinical trials and meta-analyses on the efficacy of vitamin D supplementation to prevent fractures in populations at different risks have been equivocal. The optimal level of 25-hydroxyvitamin D (25[OH]D) remains controversial. Recommendations vary between societies. The lack of standardized assays also poses a challenge in interpreting available research data.<h4>Methods</h4>We systematically searched for articles in MEDLINE database through PubMed, which included meta-analysis, systematic reviews of randomized controlled trials (RCTs) and observational studies that assessed measurement, diagnosis and treatment about vitamin D de2025-01-01T00:00:00Z20252025-04-26T12:37:34.39Z2025-04-06T13:59:57.878ZS-EPMC118367673998143010.21037/aoj-24-48