biostudies-literatureOkamoto LENCATS NIH HHSNHLBI NIH HHS489-497https://www.ebi.ac.uk/biostudies/studies/S-EPMC11839338biostudies-literatureUnknown82(3)<h4>Background</h4>The cholinesterase inhibitor pyridostigmine is used to treat orthostatic hypotension by facilitating cholinergic neurotransmission in autonomic ganglia, thereby harnessing residual sympathetic tone to increase blood pressure (BP) preferentially in the upright posture. We hypothesized that less severe autonomic impairment was associated with greater pressor responses to pyridostigmine.<h4>Methods</h4>To identify predictors of pressor response, linear regression analyses between the effect of pyridostigmine on upright BP and markers of autonomic impairment were retrospectively conducted on 38 patients who had a medication trial with pyridostigmine (60 mg single dose).<h4>Results</h4>Pyridostigmine increased upright BP by 4±2/3±2 mm Hg but with a wide range of responses (-2Hypertension (Dallas, Tex. : 1979)Clinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension.PMC11839338UL1 TR002243R01 HL161095R01 HL144568R01 HL122847R01 HL149386R01 HL142583R01 HL170140Black BKMuldowney JAWalsh ETarpara KDiedrich APeltier AOkamoto LEGamboa AHabermann RParanjape SYShibao CABiaggioni IfalseClinical Correlates of Efficacy of Pyridostigmine in the Treatment of Orthostatic Hypotension.<h4>Background</h4>The cholinesterase inhibitor pyridostigmine is used to treat orthostatic hypotension by facilitating cholinergic neurotransmission in autonomic ganglia, thereby harnessing residual sympathetic tone to increase blood pressure (BP) preferentially in the upright posture. We hypothesized that less severe autonomic impairment was associated with greater pressor responses to pyridostigmine.<h4>Methods</h4>To identify predictors of pressor response, linear regression analyses between the effect of pyridostigmine on upright BP and markers of autonomic impairment were retrospectively conducted on 38 patients who had a medication trial with pyridostigmine (60 mg single dose).<h4>Results</h4>Pyridostigmine increased upright BP by 4±2/3±2 mm Hg but with a wide range of responses (-22025-01-01T00:00:00Z2025 Mar2026-07-16T23:26:40.201Z2026-07-12T03:11:32.045ZS-EPMC118393383972705310.1161/hypertensionaha.124.2405010.1161/HYPERTENSIONAHA.124.24050