{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pina-Beltran B"],"funding":["EU Horizon 2020 program Epic-XS","European Union's Horizon 2020 research and innovation program"],"pagination":["6075"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11839926"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Chronic Kidney Disease (CKD) is associated with heightened risk of thrombosis. Prescription of anticoagulants is key to manage it; however, CKD patients have shown an increased risk of bleeding under anticoagulation therapy compared to non-CKD patients. We hypothesized that the sex could modify the metabolism of indoxyl sulfate (IS), a uremic toxin and Apixaban. Our intoxication model shows that higher doses of IS and apixaban accumulate in the plasma of female mice because of expression differences in efflux transporters and cytochromes in the liver, ileum and kidneys, when compared to males. Furthermore, we found that accumulation of apixaban in females contributes to increased bleeding. Transcriptional analysis of liver samples revealed elevated Sult1a1 but reduced Abcg2 and Cyp3a11 in "],"journal":["Scientific reports"],"pubmed_title":["Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban."],"pmcid":["PMC11839926"],"funding_grant_id":["860329 Marie-Curie ITN \"STRATEGY-CKD","0000432"],"pubmed_authors":["Pina-Beltran B","Peinado-Izaguerri J","Dimitrov D","Poitevin S","McKay N","Giot M","Saez-Rodriguez J","Pustka V","Zdrahal Z","Potesil D","Burtey S"],"additional_accession":[]},"is_claimable":false,"name":"Unveiling the role of sex in the metabolism of indoxyl sulfate and apixaban.","description":"Chronic Kidney Disease (CKD) is associated with heightened risk of thrombosis. Prescription of anticoagulants is key to manage it; however, CKD patients have shown an increased risk of bleeding under anticoagulation therapy compared to non-CKD patients. We hypothesized that the sex could modify the metabolism of indoxyl sulfate (IS), a uremic toxin and Apixaban. Our intoxication model shows that higher doses of IS and apixaban accumulate in the plasma of female mice because of expression differences in efflux transporters and cytochromes in the liver, ileum and kidneys, when compared to males. Furthermore, we found that accumulation of apixaban in females contributes to increased bleeding. Transcriptional analysis of liver samples revealed elevated Sult1a1 but reduced Abcg2 and Cyp3a11 in ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T00:31:46.246Z","creation":"2025-04-04T00:31:46.246Z"},"accession":"S-EPMC11839926","cross_references":{"pubmed":["39972038"],"doi":["10.1038/s41598-025-90405-5"]}}