{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Q"],"funding":["National Natural Science Foundation of China","Sichuan Science and Technology Program"],"pagination":["e70282"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11840698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(2)"],"pubmed_abstract":["Objective
Emerging evidence highlights the involvement of long non-coding RNAs (lncRNAs) and ferroptosis in the pathogenesis of traumatic brain injury (TBI). However, the regulatory role of lncRNAs in TBI-induced ferroptosis remains poorly understood. This study aims to investigate the role of a specific lncRNA, noncoding transcript of chemokine (C-C motif) ligand 4 (Ccl4) overlapping (Ntoco), in the regulation of ferroptosis following TBI and explore its potential as a therapeutic target.Methods
The expression levels of Ntoco following controlled cortical injury (CCI) in mice were measured using real-time PCR. Behavioral tests post-injury were assessed using the rotarod test and Morris water maze, and lesion volume was evaluated using micro-MRI. Ntoco binding proteins were"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Ntoco Promotes Ferroptosis via Hnrnpab-Mediated NF-κB/Lcn2 Axis Following Traumatic Brain Injury in Mice."],"pmcid":["PMC11840698"],"funding_grant_id":["82204368","32460218","32071182","2023NSFSC0675","32371202"],"pubmed_authors":["Li J","Wang Q","Li T","Zuo H","Wang T","Gao L","Xiao X","Luo X","Sun H","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Ntoco Promotes Ferroptosis via Hnrnpab-Mediated NF-κB/Lcn2 Axis Following Traumatic Brain Injury in Mice.","description":"Objective
Emerging evidence highlights the involvement of long non-coding RNAs (lncRNAs) and ferroptosis in the pathogenesis of traumatic brain injury (TBI). However, the regulatory role of lncRNAs in TBI-induced ferroptosis remains poorly understood. This study aims to investigate the role of a specific lncRNA, noncoding transcript of chemokine (C-C motif) ligand 4 (Ccl4) overlapping (Ntoco), in the regulation of ferroptosis following TBI and explore its potential as a therapeutic target.Methods
The expression levels of Ntoco following controlled cortical injury (CCI) in mice were measured using real-time PCR. Behavioral tests post-injury were assessed using the rotarod test and Morris water maze, and lesion volume was evaluated using micro-MRI. Ntoco binding proteins were","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-02T14:22:12.187Z","creation":"2025-04-04T02:50:59.693Z"},"accession":"S-EPMC11840698","cross_references":{"pubmed":["39976282"],"doi":["10.1111/cns.70282"]}}