{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(4)"],"submitter":["Chen Y"],"pubmed_abstract":["More and more evidences show that the imbalance of intestinal flora homeostasis can contribute to the progression of colorectal cancer (CRC). <i>Solobacterium moorei (S. moorei)</i>, an anaerobic Gram-positive bacillus, was found to be enriched in fecal samples from CRC patients. However, the signaling regulatory mechanism of <i>S. moorei</i> promoting CRC progression remain unknown. Three CRC mouse models (<i>Apc<sup>Min/+</sup></i> mice, AOM/DSS-treated mice and subcutaneous colorectal xenograft mice) and two cell lines (DLD-1 and HT-29) were used to investigate the biological functions and molecular mechanisms of <i>S. moorei</i> on tumor progression of CRC <i>in vivo</i> and <i>in vitro</i>. <i>S. moorei</i> abundance increased in fecal samples and tumor tissues, and was significantly "],"journal":["International journal of biological sciences"],"pagination":["1497-1512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11844286"],"repository":["biostudies-literature"],"pubmed_title":["<i>Solobacterium moorei</i> promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer."],"pmcid":["PMC11844286"],"pubmed_authors":["Jiang Y","Dai M","Sun Q","Guo Y","Qiu C","Zhang Y","Qin Y","Chen Y","Hao Y","Zhou Y","Fan T"],"additional_accession":[]},"is_claimable":false,"name":"<i>Solobacterium moorei</i> promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer.","description":"More and more evidences show that the imbalance of intestinal flora homeostasis can contribute to the progression of colorectal cancer (CRC). <i>Solobacterium moorei (S. moorei)</i>, an anaerobic Gram-positive bacillus, was found to be enriched in fecal samples from CRC patients. However, the signaling regulatory mechanism of <i>S. moorei</i> promoting CRC progression remain unknown. Three CRC mouse models (<i>Apc<sup>Min/+</sup></i> mice, AOM/DSS-treated mice and subcutaneous colorectal xenograft mice) and two cell lines (DLD-1 and HT-29) were used to investigate the biological functions and molecular mechanisms of <i>S. moorei</i> on tumor progression of CRC <i>in vivo</i> and <i>in vitro</i>. <i>S. moorei</i> abundance increased in fecal samples and tumor tissues, and was significantly ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2025-04-18T13:07:21.44Z","creation":"2025-04-06T22:40:48.607Z"},"accession":"S-EPMC11844286","cross_references":{"pubmed":["39990665"],"doi":["10.7150/ijbs.102742"]}}