biostudies-literatureUnknown21(4)Chen YMore and more evidences show that the imbalance of intestinal flora homeostasis can contribute to the progression of colorectal cancer (CRC). <i>Solobacterium moorei (S. moorei)</i>, an anaerobic Gram-positive bacillus, was found to be enriched in fecal samples from CRC patients. However, the signaling regulatory mechanism of <i>S. moorei</i> promoting CRC progression remain unknown. Three CRC mouse models (<i>Apc^Min/+</i> mice, AOM/DSS-treated mice and subcutaneous colorectal xenograft mice) and two cell lines (DLD-1 and HT-29) were used to investigate the biological functions and molecular mechanisms of <i>S. moorei</i> on tumor progression of CRC <i>in vivo</i> and <i>in vitro</i>. <i>S. moorei</i> abundance increased in fecal samples and tumor tissues, and was significantly International journal of biological sciences1497-1512https://www.ebi.ac.uk/biostudies/studies/S-EPMC11844286biostudies-literature<i>Solobacterium moorei</i> promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer.PMC11844286Jiang YDai MSun QGuo YQiu CZhang YQin YChen YHao YZhou YFan Tfalse<i>Solobacterium moorei</i> promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer.More and more evidences show that the imbalance of intestinal flora homeostasis can contribute to the progression of colorectal cancer (CRC). <i>Solobacterium moorei (S. moorei)</i>, an anaerobic Gram-positive bacillus, was found to be enriched in fecal samples from CRC patients. However, the signaling regulatory mechanism of <i>S. moorei</i> promoting CRC progression remain unknown. Three CRC mouse models (<i>Apc^Min/+</i> mice, AOM/DSS-treated mice and subcutaneous colorectal xenograft mice) and two cell lines (DLD-1 and HT-29) were used to investigate the biological functions and molecular mechanisms of <i>S. moorei</i> on tumor progression of CRC <i>in vivo</i> and <i>in vitro</i>. <i>S. moorei</i> abundance increased in fecal samples and tumor tissues, and was significantly 2025-01-01T00:00:00Z20252025-04-18T13:07:21.44Z2025-04-06T22:40:48.607ZS-EPMC118442863999066510.7150/ijbs.102742