{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Huang Y"],"funding":["NIAID NIH HHS"],"pubmed_abstract":["Synergy of antimicrobial combinations was tested against contemporary <i>Mycobacteroides</i> abscessus isolates using 2-D and 3-D checkerboard assays. Triple combinations of omadacycline-azithromycin-clofazimine, tigecycline-azithromycin-clofazimine, omadacycline-azithromycin-linezolid and omadacycline-azithromycin-contezolid demonstrated synergy (FIC ≤ 0.5) against 33%, 31%, 62%, and 66% of isolates, respectively. Notably, in all triple combinations, macrolide resistant <i>M. abscessus</i> subsp. <i>abscessus</i> and <i>M. abscessus</i> subsp. <i>bolletii</i> isolates were fully sensitized to azithromycin at the FIC index, as were isolates with elevated clofazimine MICs."],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.02.13.638181"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11844545"],"repository":["biostudies-literature"],"pubmed_title":["Triple antimicrobial combinations with potent synergistic activity against &lt;i&gt;M. abscessus&lt;/i&gt;."],"pmcid":["PMC11844545"],"funding_grant_id":["T32 AI007061"],"pubmed_authors":["Huang Y","Bode-Sojobi I","Chiaraviglio L","Kirby JE"],"additional_accession":[]},"is_claimable":false,"name":"Triple antimicrobial combinations with potent synergistic activity against &lt;i&gt;M. abscessus&lt;/i&gt;.","description":"Synergy of antimicrobial combinations was tested against contemporary <i>Mycobacteroides</i> abscessus isolates using 2-D and 3-D checkerboard assays. Triple combinations of omadacycline-azithromycin-clofazimine, tigecycline-azithromycin-clofazimine, omadacycline-azithromycin-linezolid and omadacycline-azithromycin-contezolid demonstrated synergy (FIC ≤ 0.5) against 33%, 31%, 62%, and 66% of isolates, respectively. Notably, in all triple combinations, macrolide resistant <i>M. abscessus</i> subsp. <i>abscessus</i> and <i>M. abscessus</i> subsp. <i>bolletii</i> isolates were fully sensitized to azithromycin at the FIC index, as were isolates with elevated clofazimine MICs.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-04-08T19:02:45.137Z","creation":"2025-06-26T03:06:03.665Z"},"accession":"S-EPMC11844545","cross_references":{"pubmed":["39990351"],"doi":["10.1101/2025.02.13.638181"]}}