biostudies-literatureWeiss JEuropean Research CouncilEuropean Union-European Research CouncilNCI NIH HHSNIH HHSDeutsche Forschungsgemeinschaft (DFG, German Research Foundation276-288https://www.ebi.ac.uk/biostudies/studies/S-EPMC11846076biostudies-literatureUnknown297(3)<h4>Background</h4>Steatotic liver disease (SLD) is a potentially reversible condition but often goes unnoticed with the risk for end-stage liver disease.<h4>Purpose</h4>To opportunistically estimate SLD on lung screening chest computed tomography (CT) and investigate its prognostic value in heavy smokers participating in the National Lung Screening Trial (NLST).<h4>Material and methods</h4>We used a deep learning model to segment the liver on non-contrast-enhanced chest CT scans of 19,774 NLST participants (age 61.4 ± 5.0 years; 41.2% female) at baseline and on the 1-year follow-up scan if no cancer was detected. SLD was defined as hepatic fat fraction (HFF) ≥5% derived from Hounsfield unit measures of the segmented liver. Participants with SLD were categorized as lean (body mass index [BJournal of internal medicineOpportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals.PMC11846076866504NIH-USA U01CA190234U24 CA194354U01 CA190234502050303NIH (NCI) 5U01CA209414NIH-USA U24CA194354U01 CA209414NIH-USA R35CA22052NIH-USA U01CA209414Weiss JFedorov AJohnson JMak RHThiriveedhi VLu MTAerts HJWLBernatz SfalseOpportunistic assessment of steatotic liver disease in lung cancer screening eligible individuals.<h4>Background</h4>Steatotic liver disease (SLD) is a potentially reversible condition but often goes unnoticed with the risk for end-stage liver disease.<h4>Purpose</h4>To opportunistically estimate SLD on lung screening chest computed tomography (CT) and investigate its prognostic value in heavy smokers participating in the National Lung Screening Trial (NLST).<h4>Material and methods</h4>We used a deep learning model to segment the liver on non-contrast-enhanced chest CT scans of 19,774 NLST participants (age 61.4 ± 5.0 years; 41.2% female) at baseline and on the 1-year follow-up scan if no cancer was detected. SLD was defined as hepatic fat fraction (HFF) ≥5% derived from Hounsfield unit measures of the segmented liver. Participants with SLD were categorized as lean (body mass index [B2025-01-01T00:00:00Z2025 Mar2026-06-03T04:50:38.512Z2025-04-04T00:16:18.085ZS-EPMC118460763986888910.1111/joim.20053