{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mulamba C"],"funding":["European & Developing Countries Clinical Trials Partnership (EDCTP)"],"pagination":["54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11846475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Malaria transmission depends on the presence of gametocytes in the peripheral blood of infected human hosts. Understanding malaria infectious reservoirs enables transmission-blocking interventions to target the most important hosts for the disease. This study characterized the distribution of gametocyte carriage as a baseline for the clinical evaluation of a Pfs25-based transmission-blocking vaccine candidate in Bagamoyo, Tanzania.<h4>Methods</h4>A malaria survey was conducted in five locations from May to August 2022. A total of 467 participants-192 children (5-12 years), 65 adolescents (13-17 years) and 210 adults (18-45 years)-were enrolled. Malaria was detected using three methods: rapid diagnostic tests, light microscopy and quantitative polymerase chain reaction. T"],"journal":["Malaria journal"],"pubmed_title":["Plasmodium falciparum gametocyte burden in a Tanzanian heterogeneous transmission setting."],"pmcid":["PMC11846475"],"funding_grant_id":["RIA2016V-1649"],"pubmed_authors":["Lazaro LO","Kreppel K","Mulamba C","Odufuwa OG","Olotu AI","Kweyamba PA","Williams CL","Chabo MS","Kamage JJ"],"additional_accession":[]},"is_claimable":false,"name":"Plasmodium falciparum gametocyte burden in a Tanzanian heterogeneous transmission setting.","description":"<h4>Background</h4>Malaria transmission depends on the presence of gametocytes in the peripheral blood of infected human hosts. Understanding malaria infectious reservoirs enables transmission-blocking interventions to target the most important hosts for the disease. This study characterized the distribution of gametocyte carriage as a baseline for the clinical evaluation of a Pfs25-based transmission-blocking vaccine candidate in Bagamoyo, Tanzania.<h4>Methods</h4>A malaria survey was conducted in five locations from May to August 2022. A total of 467 participants-192 children (5-12 years), 65 adolescents (13-17 years) and 210 adults (18-45 years)-were enrolled. Malaria was detected using three methods: rapid diagnostic tests, light microscopy and quantitative polymerase chain reaction. T","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T07:32:49.511Z","creation":"2025-04-04T07:32:49.511Z"},"accession":"S-EPMC11846475","cross_references":{"pubmed":["39985008"],"doi":["10.1186/s12936-025-05270-4"]}}