{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Liu TH"],"funding":["National Natural Science Foundation of China"],"pubmed_abstract":["Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in respon"],"journal":["NPJ biofilms and microbiomes"],"pagination":["34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11846869"],"repository":["biostudies-literature"],"pubmed_title":["Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis."],"pmcid":["PMC11846869"],"pubmed_authors":["Xue YZ","Liu TH","Xie T","Bai ZY","Chen MH","Chen LG","Xiao Y","Hao H","Wei H","Wang JW","Zhang S","Zhang CY"],"additional_accession":[]},"is_claimable":false,"name":"Hypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.","description":"Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in respon","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T21:58:14.834Z","creation":"2025-04-06T22:29:09.558Z"},"accession":"S-EPMC11846869","cross_references":{"pubmed":["39987250"],"doi":["10.1038/s41522-025-00645-6"]}}