biostudies-literatureUnknown11(1)Liu THNational Natural Science Foundation of ChinaGut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in responNPJ biofilms and microbiomes34https://www.ebi.ac.uk/biostudies/studies/S-EPMC11846869biostudies-literatureHypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.PMC11846869Xue YZLiu THXie TBai ZYChen MHChen LGXiao YHao HWei HWang JWZhang SZhang CYfalseHypertension inhibition by Dubosiella newyorkensis via reducing pentosidine synthesis.Gut dysbiosis has been associated with hypertension. Herein, we aimed to discover the potential association between gut microbiota and high-salt diet (HSD) induced endothelial dysfunction in conventional hypertensive mice. Dubosiella newyorkensis was found highly sensitive to salt in HSD-induced hypertension. The salt-sensitive nature of Dubosiella newyorkensis was confirmed by bacteria culture in vitro. Oral Dubosiella newyorkensis in HSD-induced hypertensive mice decreased blood pressure, inhibited activation of vascular endothelium, attenuated inflammation and alleviated intestinal vascular barrier injury. Similar effects of Dubosiella newyorkensis were observed in germ-free mice. Interestingly, serum pentosidine was found to function as a biomarker for Dubosiella newyorkensis in respon2025-01-01T00:00:00Z2025 Feb2026-06-01T21:58:14.834Z2025-04-06T22:29:09.558ZS-EPMC118468693998725010.1038/s41522-025-00645-6