{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Carbonell F"],"funding":["The Canadian Institutes of Health Research","Lumosity","NIBIB NIH HHS","NIA NIH HHS","Janssen Alzheimer Immunotherapy Research & Development","Alzheimer's Drug Discovery Foundation","Cogstate","IXICO Ltd.","Eisai Inc.","Meso Scale Diagnostics","GE Healthcare","W81XWH-12-2-0012","Eli Lilly and Company","CereSpir, Inc.","Fujirebio","Transition Therapeutics","Novartis Pharmaceuticals Corporation","EuroImmun","Araclon Biotech","Alzheimer's Association","NIH HHS","Johnson & Johnson Pharmaceutical Research & Development LLC","Servier; Takeda Pharmaceutical Company","Elan Pharmaceuticals, Inc.","Neurotrack Technologies","AbbVie","BioClinica, Inc.","Department of Defense","Bristol-Myers Squibb Company","Piramal Imaging","NeuroRx Research","Alzheimer's Disease Neuroimaging Initiative","Biospective Inc","Biogen"],"pagination":["e14625"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11848043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(2)"],"pubmed_abstract":["<h4>Introduction</h4>Positron emission tomography (PET) imaging studies have shown that amyloid beta (Aβ) is significantly correlated with glucose metabolism in mild cognitive impairment independently of the apolipoprotein E (APOE) ε4 genotype.<h4>Methods</h4>We used a singular value decomposition (SVD) approach to pairwise cross-correlation among tau, Aβ, and fluorodeoxyglucose PET images. The resulting SVD-based tau and Aβ scores as well as the APOE ε4 genotype, were entered as predictors in a voxelwise general linear model for statistical assessment of their effect on FDG.<h4>Results</h4>We found cortical regions where a reduced glucose metabolism was maximally correlated with distributed patterns of tau, accounting for the effect of Aβ and APOE ε4 genotype.<h4>Discussion</h4>By highlighting the more significant role of tau, rather than Aβ, in the reduction of glucose metabolism, our results provide a better understanding of their combined effect in the development and progression of Alzheimer's disease.<h4>Highlights</h4>This study uses a data-driven singular value decomposition approach to the cross-correlation matrix between tau and fluorodeoxyglucose (FDG) images, as well as between FDG and amyloid beta (Aβ) positron emission tomography (PET) images. From a population of mild cognitive impairment subjects, we found that spatially distributed scores of tau PET are associated with an even stronger reduction of glucose metabolism, independent of the apolipoprotein E ε4 genotype and confounded by Aβ. By highlighting the more significant role of tau, rather than Aβ, on the reduction of glucose metabolism, our results provide a better understanding of their combined effects in the development of Alzheimer's disease."],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ."],"pmcid":["PMC11848043"],"funding_grant_id":["U01 AG024904"],"pubmed_authors":["Alzheimer's Disease Neuroimaging Initiative","Bedell BJ","McNicoll C","Carbonell F","Zijdenbos AP"],"additional_accession":[]},"is_claimable":false,"name":"Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ.","description":"<h4>Introduction</h4>Positron emission tomography (PET) imaging studies have shown that amyloid beta (Aβ) is significantly correlated with glucose metabolism in mild cognitive impairment independently of the apolipoprotein E (APOE) ε4 genotype.<h4>Methods</h4>We used a singular value decomposition (SVD) approach to pairwise cross-correlation among tau, Aβ, and fluorodeoxyglucose PET images. The resulting SVD-based tau and Aβ scores as well as the APOE ε4 genotype, were entered as predictors in a voxelwise general linear model for statistical assessment of their effect on FDG.<h4>Results</h4>We found cortical regions where a reduced glucose metabolism was maximally correlated with distributed patterns of tau, accounting for the effect of Aβ and APOE ε4 genotype.<h4>Discussion</h4>By highlighting the more significant role of tau, rather than Aβ, in the reduction of glucose metabolism, our results provide a better understanding of their combined effect in the development and progression of Alzheimer's disease.<h4>Highlights</h4>This study uses a data-driven singular value decomposition approach to the cross-correlation matrix between tau and fluorodeoxyglucose (FDG) images, as well as between FDG and amyloid beta (Aβ) positron emission tomography (PET) images. From a population of mild cognitive impairment subjects, we found that spatially distributed scores of tau PET are associated with an even stronger reduction of glucose metabolism, independent of the apolipoprotein E ε4 genotype and confounded by Aβ. By highlighting the more significant role of tau, rather than Aβ, on the reduction of glucose metabolism, our results provide a better understanding of their combined effects in the development of Alzheimer's disease.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-22T18:47:35.703Z","creation":"2025-04-06T02:37:49.311Z"},"accession":"S-EPMC11848043","cross_references":{"pubmed":["39989007"],"doi":["10.1002/alz.14625"]}}