{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zalma BA"],"funding":["NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","Virginia and D K Ludwig Fund for Cancer Research"],"pagination":["108171"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11850126"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["301(2)"],"pubmed_abstract":["Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of the integrated stress response (ISR) in the liver and can upregulate autophagy in some cell types. We hypothesized that autophagy-related 7 (ATG7), a protein that is essential for autophagy and an ISR target gene, was necessary during exposure to asparaginase to maintain liver health. We knocked down Atg7 systemically (Atg7<sup>Δ/Δ</sup>) or in hepatocytes only (ls-Atg7KO) in mice before exposure to pegylated asparaginase for 5 days. Intact mice injected with asparaginase lost body weight due to reduced food intake and increased energy expenditure. Systemic Atg7 ablation reduced liver protein synthesis and increased liver injury in vehicle-injected mice but did not further reduce liver protein synthesis, "],"journal":["The Journal of biological chemistry"],"pubmed_title":["Autophagy-related 7 (ATG7) regulates food intake and liver health during asparaginase exposure."],"pmcid":["PMC11850126"],"funding_grant_id":["R01 DK109714"],"pubmed_authors":["Rodriguez EM","Wek RC","Rodriguez-Polanco FC","Anthony TG","Zalma BA","Cararo-Lopes E","White E","Farooq SA","Bhavsar CT","Ibrahim M","Levy JL"],"additional_accession":[]},"is_claimable":false,"name":"Autophagy-related 7 (ATG7) regulates food intake and liver health during asparaginase exposure.","description":"Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of the integrated stress response (ISR) in the liver and can upregulate autophagy in some cell types. We hypothesized that autophagy-related 7 (ATG7), a protein that is essential for autophagy and an ISR target gene, was necessary during exposure to asparaginase to maintain liver health. We knocked down Atg7 systemically (Atg7<sup>Δ/Δ</sup>) or in hepatocytes only (ls-Atg7KO) in mice before exposure to pegylated asparaginase for 5 days. Intact mice injected with asparaginase lost body weight due to reduced food intake and increased energy expenditure. Systemic Atg7 ablation reduced liver protein synthesis and increased liver injury in vehicle-injected mice but did not further reduce liver protein synthesis, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-18T21:20:44.673Z","creation":"2025-04-07T09:18:11.216Z"},"accession":"S-EPMC11850126","cross_references":{"pubmed":["39798881"],"doi":["10.1016/j.jbc.2025.108171"]}}