{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(2)"],"submitter":["Camard L"],"funding":["Foundation for Medical Research","J&J Innovative Medicine","Institut Pasteur"],"pubmed_abstract":["IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood. We show that IL-23 receptors are expressed on the large majority of human mucosal-associated invariant T (MAIT), but not of conventional T cells. Protein and transcriptional profiling at the population and single cell level demonstrates that stimulation with IL-23 or the structurally related cytokine IL-12 drives distinct functional profiles, revealing a high level of plasticity of MAIT cells. IL-23, in particular, affects key molecules and pathways related to autoimmunity and cytotoxic functions. Integrated analysis of transcriptomes and chromatin accessibility, supported by CRISPR-Cas9 med"],"journal":["iScience"],"pagination":["111898"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11850163"],"repository":["biostudies-literature"],"pubmed_title":["IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells."],"pmcid":["PMC11850163"],"pubmed_authors":["Yahia-Cherbal H","Cua DJ","Camard L","Wang H","Stephen T","Pietrosemoli N","Leloup C","Cantini L","Hasan M","Baillet V","Parker R","Bianchi E","Mella S","Guillemot V","Greving C","Joyce-Shaikh B","Lopez-Maestre H","Rogge L","Capocefalo D","Eckle SBG","Marsande J","Dangien A","Fourie AM","Garro K","Sienes Bailo J"],"additional_accession":[]},"is_claimable":false,"name":"IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells.","description":"IL-23 signaling plays a key role in the pathogenesis of chronic inflammatory and infectious diseases, yet the cellular targets and signaling pathways affected by this cytokine remain poorly understood. We show that IL-23 receptors are expressed on the large majority of human mucosal-associated invariant T (MAIT), but not of conventional T cells. Protein and transcriptional profiling at the population and single cell level demonstrates that stimulation with IL-23 or the structurally related cytokine IL-12 drives distinct functional profiles, revealing a high level of plasticity of MAIT cells. IL-23, in particular, affects key molecules and pathways related to autoimmunity and cytotoxic functions. Integrated analysis of transcriptomes and chromatin accessibility, supported by CRISPR-Cas9 med","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T21:16:04.342Z","creation":"2025-04-06T10:34:18.397Z"},"accession":"S-EPMC11850163","cross_references":{"pubmed":["40008359"],"doi":["10.1016/j.isci.2025.111898"]}}