biostudies-literaturePacheco-Jaime LMinistry of Science and InnovationAEIMCIULa Marató de TV3 FoundationUnión Europea NextGenerationEUAgency for Management of University and Research GrantsUniversity of BarcelonaLa Caixa FundationGeneralitat de CatalunyaPlan de Recuperación, Transformación y ResilienciaSpanish Ministry of Science, Innovation and UniversitiesMaría de Maeztu Unit of ExcellenceSpanish Ministry of Economy and CompetitivenessInstitute of Neurosciencesfcaf070https://www.ebi.ac.uk/biostudies/studies/S-EPMC11851114biostudies-literatureUnknown7(1)It has been estimated that ∼4% of individuals infected with SARS-CoV-2 will be diagnosed with post-COVID condition. Previous studies have evidenced the presence of cognitive dysfunction and structural brain changes in infected individuals; however, the relationship between structural changes and cognitive alterations in post-COVID condition is still not clear. Consequently, the aim of this work is to study structural brain alterations in post-COVID condition patients after almost 2 years of infection and their likely relationship with patients' cognitive impairment. Additionally, the association with blood biomarkers and clinical variables was also explored. One hundred and twenty-eight individuals with post-COVID condition and 37 non-infected healthy controls from the Nautilus Project (ClBrain communicationsStructural brain changes in post-COVID condition and its relationship with cognitive impairment.PMC11851114SGR 2021SGR00801LCF/BQ/DR22/11950012TED2021-130409B-C51TED2021-130409A-C52202111-30-31-32202PANDE00053PRE2018-086675PRE2021-099674CEX2021-001159-MPrats-Paris AAlsina SForne SMunoz-Moreno JARico IArauzo VCanizares SMartin-Barcelo CPardo JRoura IBargallo NCapdevila-Lacasa CCarreras-Vidal LSegura BAriza MCampabadal AGarzon TSabe NBejar JMolina YCullell MSala-Llonch RAlmeria MNAUTILUS-Project Collaborative GroupBartes-Plans ACaballero JTayo-Juli CFerre AGarcia-Vicente CGonzalez-Aguado EReverte-Vilarroya SJunque CCasas LVega SBarrue CCortes CULozano MOltra JVazquez-Rivera SCiudad MJMaldonado-Belmonte MJForcadell-Ferreres EPacheco-Jaime LValles-Pauls BBalague-Marmana MOlive VNavarro SBernia JAHernandez AGBailles ECano NGarolera MMunoz-Padros JfalseStructural brain changes in post-COVID condition and its relationship with cognitive impairment.It has been estimated that ∼4% of individuals infected with SARS-CoV-2 will be diagnosed with post-COVID condition. Previous studies have evidenced the presence of cognitive dysfunction and structural brain changes in infected individuals; however, the relationship between structural changes and cognitive alterations in post-COVID condition is still not clear. Consequently, the aim of this work is to study structural brain alterations in post-COVID condition patients after almost 2 years of infection and their likely relationship with patients' cognitive impairment. Additionally, the association with blood biomarkers and clinical variables was also explored. One hundred and twenty-eight individuals with post-COVID condition and 37 non-infected healthy controls from the Nautilus Project (Cl2025-01-01T00:00:00Z20252026-06-03T04:41:01.76Z2025-04-04T00:21:45.498ZS-EPMC118511144000832610.1093/braincomms/fcaf070