{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bayram F"],"funding":["German Research Foundation","EU Horizon","German Cardiac Society","Else-Kröner-Fresenius Foundation","German Federal Ministry of Education and Research","German Heart Foundation (Deutsche Herzstiftung e.V.)"],"pagination":["163"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11851367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial <i>DYRK1B</i> expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined <i>DYRK1B</i> mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardia"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Myocardial <i>DYRK1B</i> Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing."],"pmcid":["PMC11851367"],"funding_grant_id":["Research Grant","doctoral network","LE 5009/3-1, project number: 528297116","project number: 2018_A159","TRR 374 grant (project number: 509149993, TPA6)","STRATIFY-HF (project number: 101080905)","Clinician Scientist Program","LE 5009/5-1, project number: 554804344","WA 2539/8-1","Heisenberg-Professorship (LE 5009/2-1, project number: 528296867)","project number: 01ZZ2324C"],"pubmed_authors":["Tafelmeier M","Schmid C","Wermers D","Maier LS","Schildt S","Lebek S","Provaznik Z","Hegner P","Bayram F","Wagner S","Arzt M","Lauerer AM","Mustroph J","Baier MJ"],"additional_accession":[]},"is_claimable":false,"name":"Myocardial <i>DYRK1B</i> Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing.","description":"Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial <i>DYRK1B</i> expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined <i>DYRK1B</i> mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardia","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-18T12:47:32.192Z","creation":"2025-04-06T22:08:18.847Z"},"accession":"S-EPMC11851367","cross_references":{"pubmed":["40002350"],"doi":["10.3390/antiox14020163"]}}