biostudies-literatureBayram FGerman Research FoundationEU HorizonGerman Cardiac SocietyElse-Kröner-Fresenius FoundationGerman Federal Ministry of Education and ResearchGerman Heart Foundation (Deutsche Herzstiftung e.V.)163https://www.ebi.ac.uk/biostudies/studies/S-EPMC11851367biostudies-literatureUnknown14(2)Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial <i>DYRK1B</i> expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined <i>DYRK1B</i> mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardiaAntioxidants (Basel, Switzerland)Myocardial <i>DYRK1B</i> Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing.PMC11851367Research Grantdoctoral networkLE 5009/3-1, project number: 528297116project number: 2018_A159TRR 374 grant (project number: 509149993, TPA6)STRATIFY-HF (project number: 101080905)Clinician Scientist ProgramLE 5009/5-1, project number: 554804344WA 2539/8-1Heisenberg-Professorship (LE 5009/2-1, project number: 528296867)project number: 01ZZ2324CTafelmeier MSchmid CWermers DMaier LSSchildt SLebek SProvaznik ZHegner PBayram FWagner SArzt MLauerer AMMustroph JBaier MJfalseMyocardial <i>DYRK1B</i> Expression Is Increased in Patients with Impaired Cardiac Contractility and Sleep-Disordered Breathing.Heart failure and cardiovascular disease represent a significant burden on healthcare systems worldwide. Recent evidence associates an increased expression of the dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) with an impaired cardiac function in mice. However, there remains a paucity of data on myocardial <i>DYRK1B</i> expression in patients with cardiovascular disease in the context of other comorbidities. In our study, we examined <i>DYRK1B</i> mRNA expression in human right atrial appendage biopsies from 159 patients undergoing elective coronary artery bypass surgery. Each patient was tested for sleep-disordered breathing the night prior to surgery. In this large representative study cohort with cardiovascular high-risk patients, we found that an impaired cardia2025-01-01T00:00:00Z2025 Jan2025-04-18T12:47:32.192Z2025-04-06T22:08:18.847ZS-EPMC118513674000235010.3390/antiox14020163