biostudies-literatureOuro AXunta de GaliciaINTERREG Atlantic AreaInstituto de Salud Carlos IIIMinisterio de Ciencia e InnovaciónINTER-REG V A España Portugal (POCTEP)CIBERNEDMarie Skłodowska-Curie grant159https://www.ebi.ac.uk/biostudies/studies/S-EPMC11851676biostudies-literatureUnknown14(2)Migraine is one of the most common neurological disorders and the second most disabling human condition. The molecular mechanisms of migraine have been linked to neuropeptide release, endothelial dysfunction, oxidative stress and inflammatory processes. Acid sphingomyelinase (aSMase) is a secreted enzyme that leads to sphingomyelin degradation to produce ceramide. Its activity has been associated with several molecular processes involved in migraine. Therefore, this cross-sectional study aims to study the potential role of aSMase in patients with episodic and chronic migraine. In this cross-sectional pilot study, serum samples from female healthy controls (n = 23), episodic migraine (EM) patients (n = 31), and chronic migraine (CM) patients (n = 28) were studied. The total serum levels of Antioxidants (Basel, Switzerland)Elevated Serum Levels of Acid Sphingomyelinase in Female Patients with Episodic and Chronic Migraine.PMC11851676PI22/00938PDC2022-134000-I000624_2IQBIONEURO_6_EIN607A2022/07101066444CB22/05/00067EAPA_791/2018_ NEUROATLANTIC projectOuro ARodriguez-Arrizabalaga MCustodia ALema ICasas JSobrino TAramburu-Nunez MRomaus-Sanjurjo DCastillo JCastro-Mosquera MDebasa-Mouce MLeira RfalseElevated Serum Levels of Acid Sphingomyelinase in Female Patients with Episodic and Chronic Migraine.Migraine is one of the most common neurological disorders and the second most disabling human condition. The molecular mechanisms of migraine have been linked to neuropeptide release, endothelial dysfunction, oxidative stress and inflammatory processes. Acid sphingomyelinase (aSMase) is a secreted enzyme that leads to sphingomyelin degradation to produce ceramide. Its activity has been associated with several molecular processes involved in migraine. Therefore, this cross-sectional study aims to study the potential role of aSMase in patients with episodic and chronic migraine. In this cross-sectional pilot study, serum samples from female healthy controls (n = 23), episodic migraine (EM) patients (n = 31), and chronic migraine (CM) patients (n = 28) were studied. The total serum levels of 2025-01-01T00:00:00Z2025 Jan2025-04-22T18:59:21.728Z2025-04-06T02:37:35.394ZS-EPMC118516764000234610.3390/antiox14020159