{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(2)"],"submitter":["Heerspink HJL"],"funding":["Bayer AG","Bayer"],"pubmed_abstract":["<h4>Background</h4>Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes in two phase 3 outcome trials. The Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates the effect of finerenone in adults with CKD without diabetes.<h4>Methods</h4>FIND-CKD (NCT05047263 and EU CT 2023-506897-11-00) is a randomized, double-blind, placebo-controlled phase 3 trial in patients with CKD of non-diabetic aetiology. Adults with a urinary albumin:creatinine ratio (UACR) ≥200-≤3500 mg/g and an estimated glomerular filtration rate (eGFR) ≥25-<90 ml/min/1.73 m2 receiving a maximum "],"journal":["Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"],"pagination":["308-319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11852274"],"repository":["biostudies-literature"],"pubmed_title":["Design and baseline characteristics of the Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) randomized trial."],"pmcid":["PMC11852274"],"pubmed_authors":["Burgner A","Chang CT","Khwaja A","Kenig Y","Wanner C","Kidokoro K","Wong AC","Gouva C","Dubois B","Kang YS","Badve S","Arunkumar S","Packham D","Petras D","Vesterinen P","He Y","Boletis I","Cherney DZI","Schloemer P","He W","Leiba A","Fiaccadori E","Lin H","Xu X","Alla S","Heerspink HJL","Brinker MD","Claes K","Rehorova J","Lee CT","Mortensen L","Kanno Y","Kendrick J","Oh JE","Segura de la Morena JJ","Ahmad MK","Nakhoul G","Meng X","Tan NC","Alves AR","Turner J","Kitagawa K","Minutolo R","Uchimura K","Costa JS","Cheng HT","Dizayee S","Bassat OK","Rozen-Zvi B","Teo J","Lee SH","Moussa J","Miyamoto K","Gray N","Bech J","Ilieva AP","Barrios C","Antropenko N","Lee SY","Aguerre P","Oshikawa J","Kotzker W","Agarwal R","Gidaro B","Szeto CC","Gelersztein E","Gupta A","Chetrit SB","Pereira T","Hernandez G","Zilahi Z","Chiu YL","Cluigt N","Birne R","Dong J","Lee JP","Santorelli G","Griffin S","Zaidman CJ","Chen X","Labriola L","Xia Y","Chen Q","Ilchev S","Li J","Maeda Y","Nakamura M","Chen J","Chen M","Chen L","Ahmad NH","Meyer J","Manllo ST","Chen C","Li W","Mazlan SAD","Hominal M","Li Y","Almeida A","Ramanathan S","Abe M","Kopyt N","Farber E","Jaras JH","Iborra PL","Loh CL","Wirth J","Neuen BL","Du J","Bamichas G","Xiong F","Amemiya M","Suzuki S","Bouarich H","Jamal A","Liu L","Jiang G","Prazny M","Lui SL","Tamura K","Ralph R","Suzuki H","Park JT","Ezhov A","Haviv Y","Lam CSP","Kirschner R","Kolkhof P","Pickett T","Halac F","Mendez R","Hansen D","Nakaya I","Umpierrez G","Stylianou K","Ueda S","Pandey R","Alicic R","Vo N","Ono M","Yamauchi A","Luo Q","Nemeth A","Luo P","Misaki T","Makita Y","Govindan S","Choi BS","Frome A","Papadopoulou D","Liu A","Liu B","Juhl C","Liu F","Kamijo Y","Castro C","Beberashvili I","Matsui M","Adnan WAHWM","Wu MJ","FIND-CKD investigators","Bucek P","Yazawa M","Khullar D","Stamova S","Chen HH","Sahay M","Cimino R","Shi Y","Grandaliano G","Papachristou E","Pedagogos E","Hornum M","Beckerman P","Donati G","La Manna G","Toda T","Newman G","Lee LY","Bayram E","Maldonado R","Hornova L","Nishi H","Bittar J","Kanai H","McCafferty K","Santana SI","Kruzel-Davila EE","Hawley C","Perkovic V","Masutani K","Lee J","Foote C","Levin-Iaina N","Lee D","Lee KW","Quadrini M","Doubel P","Chang A","Abissova T","Tang S","Pergola P","Teixeira E Costa F","Cheng H","Speeckaert M","Tang SCW","Ishii M","Kirk E","Rastogi A","Yeo SC","Mirkhel A","Doulton T","Kim S","Lee KQ","Teruel JG","Suhail SM","Fujita Y","Awad A","Fujii H","Bansal S","Lu W","Zhdanova E","Wang C","Lindhardt M","Wang D","Christiano C","Wang F","Fujisaki K","Ivanova Y","Ntounousi E","Jang HR","Fujii N","Schmidt D","Garrit JC","Wang J","Ignatius A","Fujii T","Elahi S","Toyama T","Han SY","Chahin M","Vutova T","Iwamoto T","Ako S","Toyoda M","Arriola M","Yakob S","Rodionova T","Park H","Yang M","Dimitrova I","Anand S","Yang A","Kader MASA","Rahman M","Majernikova M","Gracious N","Atta M","Yang X","Chiu PF","Han BG","Romero MS","Panse S","Hung CC","Lin SL","Long G","Long H","Chernin G","Sarafidis PA","Shimizu H","Shin SJ","Mavani S","Gregorini MC","Kim YH","Niu J","Koizumi M","Esposito C","Okada H","Bakris GL","Wahab MZA","Kovacs L","Vasileva A","Yan R","Tuttle KR","Kim YC","Maes B","Thethi T","Smith P","Smith M","Pardo SA","Fung SKS","Szelestei T","Chiang WY","Tolins J","Sarafidis P","Deben FM"],"additional_accession":[]},"is_claimable":false,"name":"Design and baseline characteristics of the Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) randomized trial.","description":"<h4>Background</h4>Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes in two phase 3 outcome trials. The Finerenone, in addition to standard of care, on the progression of kidney disease in patients with Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates the effect of finerenone in adults with CKD without diabetes.<h4>Methods</h4>FIND-CKD (NCT05047263 and EU CT 2023-506897-11-00) is a randomized, double-blind, placebo-controlled phase 3 trial in patients with CKD of non-diabetic aetiology. Adults with a urinary albumin:creatinine ratio (UACR) ≥200-≤3500 mg/g and an estimated glomerular filtration rate (eGFR) ≥25-<90 ml/min/1.73 m2 receiving a maximum ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-01T22:05:41.642Z","creation":"2025-04-04T13:46:41.499Z"},"accession":"S-EPMC11852274","cross_references":{"pubmed":["38858818"],"doi":["10.1093/ndt/gfae132"]}}