{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(2)"],"submitter":["Weidmann L"],"funding":["USZ Foundation","Baugarten Foundation","SwissLife Foundation"],"pubmed_abstract":["Background
Isolated tubulitis, borderline changes and isolated arteritis suspicious for histologic T-cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).Methods
In this single-center cohort of 326 consecutive, unselected kidney allograft biopsies assessed by histology and MMDx, we analyzed 249 cases with isolated tubulitis (i0, t1-3, v0; n = 101), borderline changes (according to Banff 2022, v0; n = 9), isolated arteritis (no borderline, v1; n = 37), no inflammation (i0, t0, v0; n = 67) and a positive control cohort (hTCMR, n = 27; mixed histologic rejection, n = 8; both acc"],"journal":["Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"],"pagination":["294-307"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11852332"],"repository":["biostudies-literature"],"pubmed_title":["Limitations of biopsy-based transcript diagnostics to detect T-cell-mediated allograft rejection."],"pmcid":["PMC11852332"],"pubmed_authors":["von Moos S","Helmchen BM","Weidmann L","Korach R","Schachtner T","Castrezana Lopez K","Rho E","Harmacek D","Gaspert A","Schmid N","Bortel N"],"additional_accession":[]},"is_claimable":false,"name":"Limitations of biopsy-based transcript diagnostics to detect T-cell-mediated allograft rejection.","description":"Background
Isolated tubulitis, borderline changes and isolated arteritis suspicious for histologic T-cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).Methods
In this single-center cohort of 326 consecutive, unselected kidney allograft biopsies assessed by histology and MMDx, we analyzed 249 cases with isolated tubulitis (i0, t1-3, v0; n = 101), borderline changes (according to Banff 2022, v0; n = 9), isolated arteritis (no borderline, v1; n = 37), no inflammation (i0, t0, v0; n = 67) and a positive control cohort (hTCMR, n = 27; mixed histologic rejection, n = 8; both acc","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-05T14:39:22.6Z","creation":"2025-04-05T14:39:22.6Z"},"accession":"S-EPMC11852332","cross_references":{"pubmed":["38925651"],"doi":["10.1093/ndt/gfae147"]}}