{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["You Z"],"funding":["Heilongjiang Postdoctoral Grant","China Postdoctoral Science Foundation","National Natural Science Foundation of China"],"pagination":["77"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11852879"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(1)"],"pubmed_abstract":["<h4>Background</h4>The pathogenesis of epilepsy is complex, and current antiepileptic drugs do not effectively control the seizures. Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates neuronal excitability, but its mechanism of action in epilepsy is not clear. In this paper, we investigated the effect of CPEB3 on seizures and elucidated its underlying molecular mechanism.<h4>Methods</h4>Bioinformatics-based search for genes closely associated with epilepsy. Changes in expression and cellular localization of CPEB3 in epilepsy were verified by western blotting (WB) and Immunofluorescence staining. Subsequently, The adeno-associated virus was employed to overexpress or knockdown in mice. Behavioral experiments verified the effect of CPEB3 on epileptic phenotype, and the m"],"journal":["Molecular medicine (Cambridge, Mass.)"],"pubmed_title":["CPEB3 can regulate seizure susceptibility by inhibiting the transcriptional activity of STAT3 on NMDARs expression."],"pmcid":["PMC11852879"],"funding_grant_id":["LBH-Q20045","LBH-Q21132","2018M640306","81871016"],"pubmed_authors":["Liu X","Liu Y","Huang C","You Z","Li J","Fan Z","Wei F","Gao X","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"CPEB3 can regulate seizure susceptibility by inhibiting the transcriptional activity of STAT3 on NMDARs expression.","description":"<h4>Background</h4>The pathogenesis of epilepsy is complex, and current antiepileptic drugs do not effectively control the seizures. Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) regulates neuronal excitability, but its mechanism of action in epilepsy is not clear. In this paper, we investigated the effect of CPEB3 on seizures and elucidated its underlying molecular mechanism.<h4>Methods</h4>Bioinformatics-based search for genes closely associated with epilepsy. Changes in expression and cellular localization of CPEB3 in epilepsy were verified by western blotting (WB) and Immunofluorescence staining. Subsequently, The adeno-associated virus was employed to overexpress or knockdown in mice. Behavioral experiments verified the effect of CPEB3 on epileptic phenotype, and the m","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-18T13:06:05.552Z","creation":"2025-04-06T22:36:18.449Z"},"accession":"S-EPMC11852879","cross_references":{"pubmed":["39994587"],"doi":["10.1186/s10020-025-01136-2"]}}