{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lopez-Ruiz M"],"funding":["División de Investigación Bogotá (DIB)-Universidad Nacional de Colombia","Wellcome Trust"],"pagination":["439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11853030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["<b>Background/Objective</b>: Finding new targets to attenuate <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is key in the development of new TB vaccines. In this context, plasma membrane P-type ATPases are relevant for mycobacterial homeostasis and virulence. In this work, we investigate the role of the copper-transporting P-type ATPase CtpA in <i>Mtb</i> virulence. <b>Methods</b>: The impact of CtpA deletion on <i>Mtb</i>'s capacity to overcome redox stress and proliferate in mouse alveolar macrophages (MH-S) was evaluated, as well as its effect on <i>Mtb</i> immunogenicity. Moreover, the influence of CtpA on the pathogenicity of <i>Mtb</i> in a mouse (BALB/c) model of progressive TB was examined. <b>Results</b>: We found that MH-S cells infected with wild-type (<i>Mtb</i>H37Rv) or the m"],"journal":["Biomedicines"],"pubmed_title":["The Plasma Membrane P-Type ATPase CtpA Is Required for <i>Mycobacterium tuberculosis</i> Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis."],"pmcid":["PMC11853030"],"funding_grant_id":["47274, 50299, 57532 and 60311","223279"],"pubmed_authors":["Lopez-Ruiz M","Maya-Hoyos M","Barrios-Payan J","Hernandez-Pando R","Mata-Espinosa D","Soto CY","Ocampo M"],"additional_accession":[]},"is_claimable":false,"name":"The Plasma Membrane P-Type ATPase CtpA Is Required for <i>Mycobacterium tuberculosis</i> Virulence in Copper-Activated Macrophages in a Mouse Model of Progressive Tuberculosis.","description":"<b>Background/Objective</b>: Finding new targets to attenuate <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) is key in the development of new TB vaccines. In this context, plasma membrane P-type ATPases are relevant for mycobacterial homeostasis and virulence. In this work, we investigate the role of the copper-transporting P-type ATPase CtpA in <i>Mtb</i> virulence. <b>Methods</b>: The impact of CtpA deletion on <i>Mtb</i>'s capacity to overcome redox stress and proliferate in mouse alveolar macrophages (MH-S) was evaluated, as well as its effect on <i>Mtb</i> immunogenicity. Moreover, the influence of CtpA on the pathogenicity of <i>Mtb</i> in a mouse (BALB/c) model of progressive TB was examined. <b>Results</b>: We found that MH-S cells infected with wild-type (<i>Mtb</i>H37Rv) or the m","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-04T10:41:43.279Z","creation":"2025-04-04T10:41:43.279Z"},"accession":"S-EPMC11853030","cross_references":{"pubmed":["40002852"],"doi":["10.3390/biomedicines13020439"]}}