{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hou SM"],"funding":["National Science and Technology Council, Taiwan","Shin Kong Wu Ho-Su Memorial Hospital","Chi Mei Medical Center-Taipei Medical University","Cathay General Hospital"],"pagination":["174"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11853366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Inflammation, a fundamental response to infection and injury, involves interactions among immune cells and signaling molecules. Dysregulated inflammation contributes to diseases such as autoimmune disorders and cancer. Interleukin-1 beta (IL-1β), produced by macrophages in response to lipoteichoic acid (LTA) from Gram-positive bacteria, is a key inflammatory mediator. Glabridin (GBD), a bioactive compound from licorice root, exhibits anti-inflammatory properties. This study investigates GBD's effects on LTA-induced proinflammatory signaling in RAW 264.7 murine macrophages and alveolar macrophages, MH-S, focusing on <i>IL-1β</i> expression and signaling pathways. Cell viability assays confirmed that 20 μM GBD was non-cytotoxic. Confocal microscopy and quantitative PCR showed that GBD signif"],"journal":["Biomolecules"],"pubmed_title":["Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages."],"pmcid":["PMC11853366"],"funding_grant_id":["2023SKHAND006","MOST 110-2320-B341-001-MY3","NSTC 113-2320-B341-002-MY3","110CM-TMU-18","CGH-MR-A11226","2024SKHAND008"],"pubmed_authors":["Hsia CH","Hou SM","Hsia CW","Cheng SW","Yang CM","Yen TL","Hsieh CY","Huang WC"],"additional_accession":[]},"is_claimable":false,"name":"Glabridin Suppresses Macrophage Activation by Lipoteichoic Acid In Vitro: The Crucial Role of MAPKs-IL-1β-iNOS Axis Signals in Peritoneal and Alveolar Macrophages.","description":"Inflammation, a fundamental response to infection and injury, involves interactions among immune cells and signaling molecules. Dysregulated inflammation contributes to diseases such as autoimmune disorders and cancer. Interleukin-1 beta (IL-1β), produced by macrophages in response to lipoteichoic acid (LTA) from Gram-positive bacteria, is a key inflammatory mediator. Glabridin (GBD), a bioactive compound from licorice root, exhibits anti-inflammatory properties. This study investigates GBD's effects on LTA-induced proinflammatory signaling in RAW 264.7 murine macrophages and alveolar macrophages, MH-S, focusing on <i>IL-1β</i> expression and signaling pathways. Cell viability assays confirmed that 20 μM GBD was non-cytotoxic. Confocal microscopy and quantitative PCR showed that GBD signif","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2025-04-22T20:07:18.333Z","creation":"2025-04-06T03:01:47.528Z"},"accession":"S-EPMC11853366","cross_references":{"pubmed":["40001477"],"doi":["10.3390/biom15020174"]}}