{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chuang TD"],"funding":["NICHD NIH HHS","NIH HHS"],"pagination":["1688"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11854932"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(4)"],"pubmed_abstract":["We performed next-generation sequencing (NGS) on RNA from 19 paired leiomyoma (Lyo) and myometrium (Myo) specimens, stratified by race/ethnicity (White: n = 7; Black: n = 12) and mediator complex subunit 12 (MED12) mutation status (mutated: n = 10; non-mutated: n = 9). Analysis identified 2,189 small non-coding RNAs (sncRNAs) with altered expression in Lyo compared to paired Myo (≥1.5-fold change), including small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs). Among these, 17 sncRNAs showed differential expression in the MED12-mutated group versus Myo, while minimal changes were observed in the non-mutated group. Additionally, 31 sncRNAs displayed differential expression in Black women compared to White women. For validation, "],"journal":["International journal of molecular sciences"],"pubmed_title":["Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas."],"pmcid":["PMC11854932"],"funding_grant_id":["R01 HD109286","HD100529","R03 HD101852","HD109286","HD101852","R01 HD100529"],"pubmed_authors":["Ton N","Baghdasarian D","Chuang TD","Rysling S","Khorram O"],"additional_accession":[]},"is_claimable":false,"name":"Differential Expression of Small Non-Coding RNAs in Uterine Leiomyomas.","description":"We performed next-generation sequencing (NGS) on RNA from 19 paired leiomyoma (Lyo) and myometrium (Myo) specimens, stratified by race/ethnicity (White: n = 7; Black: n = 12) and mediator complex subunit 12 (MED12) mutation status (mutated: n = 10; non-mutated: n = 9). Analysis identified 2,189 small non-coding RNAs (sncRNAs) with altered expression in Lyo compared to paired Myo (≥1.5-fold change), including small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), microRNAs (miRNAs), and PIWI-interacting RNAs (piRNAs). Among these, 17 sncRNAs showed differential expression in the MED12-mutated group versus Myo, while minimal changes were observed in the non-mutated group. Additionally, 31 sncRNAs displayed differential expression in Black women compared to White women. For validation, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-26T20:12:41.988Z","creation":"2025-04-07T07:47:02.478Z"},"accession":"S-EPMC11854932","cross_references":{"pubmed":["40004152"],"doi":["10.3390/ijms26041688"]}}