{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu S"],"funding":["National Natural Science Foundation of China","Natural Science Basic Research Program of Shaanxi Province"],"pagination":["1472"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11855083"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(4)"],"pubmed_abstract":["The type VI secretion system (T6SS) is a widely distributed molecular apparatus found in most Gram-negative bacteria. Studies show that T6SSs have functions in bacterial virulence, inter- and intra-bacterial competition, and environmental adaptation. <i>Pseudomonas aeruginosa</i>, an opportunistic pathogen, harbors three T6SS gene clusters that perform diverse roles in clinical infection. Herein, using DNA affinity chromatography of the H1-T6SS promoter, the fluoroquinolone antibiotic resistance regulator NfxB was identified. Further studies demonstrated that NfxB negatively regulates the expression of H1-T6SS by directly binding to its promoter region. T6SS expression and effector secretion are regulated by the fluoroquinolone antibiotic via NfxB, which enhances inter-bacterial competitio"],"journal":["International journal of molecular sciences"],"pubmed_title":["Regulation of the H1 Type VI Secretion System by the Transcriptional Regulator NfxB in <i>Pseudomonas aeruginosa</i>."],"pmcid":["PMC11855083"],"funding_grant_id":["32270195","2022JQ-184 and 2024JC-YBQN-0176"],"pubmed_authors":["Cao L","Liu L","Liu Q","Liu S","Yan W","Zhao Y","Li M","Wu Z","Yang Y","Zhang Y","Wang T","Tao R","Gao T"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of the H1 Type VI Secretion System by the Transcriptional Regulator NfxB in <i>Pseudomonas aeruginosa</i>.","description":"The type VI secretion system (T6SS) is a widely distributed molecular apparatus found in most Gram-negative bacteria. Studies show that T6SSs have functions in bacterial virulence, inter- and intra-bacterial competition, and environmental adaptation. <i>Pseudomonas aeruginosa</i>, an opportunistic pathogen, harbors three T6SS gene clusters that perform diverse roles in clinical infection. Herein, using DNA affinity chromatography of the H1-T6SS promoter, the fluoroquinolone antibiotic resistance regulator NfxB was identified. Further studies demonstrated that NfxB negatively regulates the expression of H1-T6SS by directly binding to its promoter region. T6SS expression and effector secretion are regulated by the fluoroquinolone antibiotic via NfxB, which enhances inter-bacterial competitio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-04-21T17:09:45.319Z","creation":"2025-04-21T17:09:45.319Z"},"accession":"S-EPMC11855083","cross_references":{"pubmed":["40003937"],"doi":["10.3390/ijms26041472"]}}