{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zang P"],"funding":["Henan Natural Science Foundation of Excellent Young Scholars"],"pagination":["724"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11858084"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["<b>Background/Objectives</b>: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health. <i>Hericium erinaceus</i>, a plant recognized for its dual use as food and medicine, contains a key functional component called <i>Hericium erinaceus</i> polysaccharide (HEP), which is purported to promote gastrointestinal health. This study aims to investigate the protective effects of HEP against gastrointestinal disturbances induced by simulated weightlessness and to elucidate its regulatory mechanisms. <b>Methods</b>: Sprague Dawley rats subjected to a tail suspension model were administered either a standard diet or a diet supplemented with 0.125% HEP over a period of 4 weeks (the intake of HEP is"],"journal":["Nutrients"],"pubmed_title":["Alteration of Gastrointestinal Function and the Ameliorative Effects of &lt;i&gt;Hericium erinaceus&lt;/i&gt; Polysaccharides in Tail Suspension Rats."],"pmcid":["PMC11858084"],"funding_grant_id":["242300421105"],"pubmed_authors":["Xu N","Chen P","Chen J","Huang J","Sun B","Zhang L","Liu S","Zang P","Liu W","Hou L","Ren F","Wang P","Dong H","Wang W","Lan H","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Alteration of Gastrointestinal Function and the Ameliorative Effects of &lt;i&gt;Hericium erinaceus&lt;/i&gt; Polysaccharides in Tail Suspension Rats.","description":"<b>Background/Objectives</b>: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health. <i>Hericium erinaceus</i>, a plant recognized for its dual use as food and medicine, contains a key functional component called <i>Hericium erinaceus</i> polysaccharide (HEP), which is purported to promote gastrointestinal health. This study aims to investigate the protective effects of HEP against gastrointestinal disturbances induced by simulated weightlessness and to elucidate its regulatory mechanisms. <b>Methods</b>: Sprague Dawley rats subjected to a tail suspension model were administered either a standard diet or a diet supplemented with 0.125% HEP over a period of 4 weeks (the intake of HEP is","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-05-22T03:21:11.652Z","creation":"2025-04-04T13:46:44.025Z"},"accession":"S-EPMC11858084","cross_references":{"pubmed":["40005052"],"doi":["10.3390/nu17040724"]}}